Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 8/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.47 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | STAMBP | O95630 | 1/20 | 0.47 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | WNT3A | P56704 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16495686 | 0.91 | HPGDS (0.58) | HPGDSKMT2ASTAMBPCOPS5 | |
| SCHEMBL16496190 | 0.89 | HPGDS (0.61) | HPGDSPRKAA2HTR2CMCHR1AKR1C4 | |
| SCHEMBL16495972 | 0.88 | HPGDS (0.60) | HPGDSMEN1KMT2ASMN1; SMN2STAMBP | |
| SCHEMBL16495630 | 0.88 | HPGDS (0.77) | HPGDSPRKAA2COPS5ROCK1EPHX2 | |
| SCHEMBL16495980 | 0.87 | HPGDS (0.59) | HPGDSMEN1KMT2ASMN1; SMN2STAMBP | |
| SCHEMBL16495417 | 0.87 | HPGDS (0.61) | HPGDSMEN1KMT2APRKAA2HTR2C | |
| SCHEMBL16495855 | 0.87 | HPGDS (0.61) | HPGDSPRKAA2HTR2CMCHR1STAMBP | |
| SCHEMBL16497295 | 0.87 | HPGDS (0.60) | HPGDSMEN1KMT2ASMN1; SMN2PRKAA2 | |
| SCHEMBL16495963 | 0.87 | HPGDS (0.79) | HPGDSMEN1KMT2ASMN1; SMN2EPHX2 | |
| SCHEMBL16495631 | 0.87 | HPGDS (0.67) | HPGDSPRKAA2HTR2CMCHR1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | CRAWFORTH JAMES MICHAEL (GB) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | NNT, NAMPT, NQO1 | HPGDS 1073/4885MEN1 2257/4885KMT2A 3206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.