Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | STAMBP | O95630 | 1/20 | 0.56 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KDM1A | O60341 | 4/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | ERN1 | O75460 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16495481 | 0.91 | HPGDS (0.59) | HPGDSSTAMBPCOPS5KMT2A | |
| SCHEMBL16495431 | 0.90 | HPGDS (0.61) | HPGDSNPC1RAB9ASTAMBPCOPS5 | |
| SCHEMBL16496286 | 0.89 | ROCK1 (0.58) | HPGDSMAPTTP53MMP13CYP3A4 | |
| SCHEMBL16496190 | 0.88 | HPGDS (0.61) | HPGDSSTAMBPCOPS5KDM1AHDAC1 | |
| SCHEMBL16496156 | 0.88 | NPC1 (0.55) | HPGDSNPC1RAB9AMAPTTP53 | |
| SCHEMBL16496148 | 0.87 | TRPV1 (0.47) | HPGDSNPC1RAB9ASTAMBPCOPS5 | |
| SCHEMBL16495407 | 0.87 | MAPT (0.62) | HPGDSNPC1RAB9ASTAMBPCOPS5 | |
| SCHEMBL16495630 | 0.87 | HPGDS (0.77) | HPGDSCOPS5 | |
| SCHEMBL16496009 | 0.87 | HPGDS (0.77) | HPGDSNPC1RAB9ASTAMBPCOPS5 | |
| SCHEMBL16495855 | 0.86 | HPGDS (0.61) | HPGDSSTAMBPCOPS5TP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | CRAWFORTH JAMES MICHAEL (GB) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | NNT, NAMPT, NQO1 | HPGDS 1073/4885NPC1 236/4885RAB9A 2122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.