Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 5/20 | 0.61 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | GRM5 | P41594 | 2/20 | 0.52 |
| ▸ | NAMPT | P43490 | 2/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | WNT3A | P56704 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1543648 | 0.89 | HPGDS (0.71) | HPGDSGRM5GABRA5MAP4K4 | |
| SCHEMBL16496137 | 0.88 | HPGDS (0.67) | HPGDSCNR2GRM5GABRA5MAP4K4 | |
| SCHEMBL1543445 | 0.87 | HPGDS (0.61) | HPGDSGRM5GABRA5MAP4K4WNT3A | |
| SCHEMBL1543340 | 0.87 | HPGDS (0.74) | HPGDSGRM5GABRA5MAP4K4 | |
| SCHEMBL2991461 | 0.86 | HPGDS (0.58) | HPGDSGRM5NAMPTGABRA5MAP4K4 | |
| SCHEMBL2991465 | 0.86 | HPGDS (0.58) | HPGDSGRM5NAMPTGABRA5MAP4K4 | |
| SCHEMBL13240693 | 0.84 | HPGDS (0.58) | HPGDSGRM5GABRA5WNT3A | |
| SCHEMBL13240692 | 0.84 | HPGDS (0.58) | HPGDSGRM5GABRA5WNT3A | |
| SCHEMBL16495594 | 0.84 | GABRA5 (0.53) | HPGDSCNR2NAMPTGABRA5GSK3B | |
| SCHEMBL13266065 | 0.84 | HPGDS (0.59) | HPGDSGRM5GABRA5MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | CRAWFORTH JAMES MICHAEL (GB) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | NNT, NAMPT, NQO1 | HPGDS 1073/4885CNR2 372/4885GRM5 3155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.