Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPN | P05981 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.49 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.49 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.49 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | RXRB | P28702 | 1/20 | 0.48 |
| ▸ | RXRG | P48443 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2721413 | 0.84 | HPN (0.50) | HPNP2RY14F2HDAC6PTGDR2 | |
| SCHEMBL164956 | 0.84 | CASP3 (0.57) | HPNCASP3SENP8SENP7SENP6 | |
| SCHEMBL27077479 | 0.83 | P2RY14 (0.54) | CASP3SENP8SENP7SENP6MAPK1 | |
| SCHEMBL29893069 | 0.83 | P2RY14 (0.54) | CASP3SENP8SENP7SENP6MAPK1 | |
| SCHEMBL29784265 | 0.82 | CASP3 (0.77) | HPNCASP3SENP8SENP7SENP6 | |
| SCHEMBL979496 | 0.82 | CASP3 (0.77) | HPNCASP3SENP8SENP7SENP6 | |
| SCHEMBL11565448 | 0.81 | CHEK2 (0.67) | HPNCASP3SENP8SENP7SENP6 | |
| SCHEMBL4334503 | 0.81 | CASP3 (0.57) | CASP3SENP8SENP7SENP6F2 | |
| SCHEMBL693160 | 0.81 | F2 (0.58) | HPNCASP3SENP8SENP7SENP6 | |
| SCHEMBL11563588 | 0.81 | CASP3 (0.57) | CASP3SENP8SENP7SENP6MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611774-A1 | DI-AZETIDINYL DIAMIDE AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030907-A1 | DI-AZETIDINYL DIAMIDE AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-08 | — | — | WO | disclosed |