Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 6/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16498519 | 0.88 | SCN9A (0.40) | NR1I2SCN9ASCN5ACYP3A4CYP2C9 | |
| SCHEMBL16498955 | 0.85 | KDM4E (0.42) | KDM4EALDH1A1LMNAGLAPKM | |
| SCHEMBL16512791 | 0.82 | KDM4E (0.36) | CYP3A4CYP2C9CYP2C19KDM4EALDH1A1 | |
| SCHEMBL16498257 | 0.81 | CHEK1 (0.47) | LMNAPKMKEAP1NFE2L2NPC1 | |
| SCHEMBL16498417 | 0.81 | KDM4E (0.46) | CYP3A4CYP2C9CYP2C19KDM4EALDH1A1 | |
| SCHEMBL16499092 | 0.80 | CHEK1 (0.48) | LMNAPKMKEAP1NFE2L2NPC1 | |
| SCHEMBL16498540 | 0.80 | CHEK1 (0.45) | ALDH1A1LMNAPKMHPGDKEAP1 | |
| SCHEMBL16498860 | 0.78 | DGAT2 (0.40) | CYP3A4CYP2C9CYP2C19TSHRNPSR1 | |
| SCHEMBL16498469 | 0.78 | HPGD (0.47) | CYP3A4CYP2C9CYP2C19KDM4EALDH1A1 | |
| SCHEMBL16498543 | 0.77 | CYP3A4 (0.46) | CYP3A4CYP2C9CYP2C19CFTRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011153588-A1 | VIRAL POLYMERASE INHIBITORS | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2011-12-15 | — | — | WO | claimed |
| WO-2011153588-A1 | VIRAL POLYMERASE INHIBITORS | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2011-12-15 | — | — | WO | disclosed |