Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | NEK2 | P51955 | 1/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16498257 | 0.99 | CHEK1 (0.47) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL16498540 | 0.89 | CHEK1 (0.45) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL16498500 | 0.89 | KMO (0.42) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL16498955 | 0.86 | KDM4E (0.42) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL16498513 | 0.85 | TP53 (0.46) | LMNATP53HSD17B10GAAHSD11B1 | |
| SCHEMBL16498122 | 0.85 | POLB (0.47) | SMN1; SMN2POLB | |
| SCHEMBL16512387 | 0.84 | KMO (0.42) | KMORAB9ANPC1PKMHCAR3 | |
| SCHEMBL16498417 | 0.82 | KDM4E (0.46) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL16498519 | 0.81 | SCN9A (0.40) | RAB9ANPC1PKMLMNATP53 | |
| SCHEMBL16498860 | 0.81 | DGAT2 (0.40) | CHEK1AURKACSNK1A1CDK8NEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011153588-A1 | VIRAL POLYMERASE INHIBITORS | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2011-12-15 | — | — | WO | claimed |