Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 10/20 | 0.78 |
| ▸ | VKORC1 | Q9BQB6 | 7/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.59 |
| ▸ | PCSK7 | Q16549 | 1/20 | 0.59 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7354617 | 0.88 | NQO1 (1.00) | NQO1VKORC1MEN1KMT2AABCB11 | |
| SCHEMBL29655586 | 0.88 | NQO1 (0.79) | NQO1VKORC1MEN1KMT2AABCB11 | |
| SCHEMBL1649892 | 0.88 | NQO1 (0.79) | NQO1VKORC1MEN1KMT2AABCB11 | |
| SCHEMBL4958234 | 0.87 | NQO1 (0.73) | NQO1VKORC1MEN1KMT2AABCB11 | |
| SCHEMBL1649924 | 0.85 | NQO1 (0.69) | NQO1VKORC1MEN1KMT2AABCB11 | |
| Benzoic Acid SCHEMBL27687937 | 0.82 | NQO1 (0.73) | NQO1VKORC1MEN1KMT2AABCB11 | |
| SCHEMBL1648186 | 0.79 | NQO1 (1.00) | NQO1VKORC1MEN1KMT2AABCB11 | |
| SCHEMBL13498415 | 0.79 | NQO1 (0.72) | NQO1VKORC1MEN1KMT2AABCB11 | |
| SCHEMBL1648030 | 0.79 | NQO1 (0.68) | NQO1VKORC1MEN1KMT2AABCB11 | |
| SCHEMBL28765897 | 0.78 | NQO1 (0.63) | NQO1VKORC1MEN1KMT2AABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2161261-B1 | Materials and methods for treating coagulation disorders | ARMETHEON INC (US) | 2013-08-28 | — | — | EP | disclosed |
| US-7932405-B2 | Halogenated ester derivatives of coumarins for the treatment of coagulation disorders | ARYX THERAPEUTICS, INC. (US) | 2011-04-26 | — | — | US | disclosed |
| EP-2161261-A1 | Materials and methods for treating coagulation disorders | Aryx Therapeutics (US) | 2010-03-10 | — | — | EP | disclosed |
| US-7666902-B2 | 1,1,1,3,3,3-hexachloro-2-methylpropan-2-yl 4-((4-hydroxy-2-oxo-2H-chromen-3-yl)methyl)benzoate; side effect reduction over warfarin | ARYX THERAPEUTICS, INC. (US) | 2010-02-23 | — | — | US | disclosed |
| EP-1735296-B1 | MATERIALS AND METHODS FOR TREATING COAGULATION DISORDERS | ARYX THERAPEUTICS (US) | 2009-12-09 | — | — | EP | disclosed |
| US-20090082430-A1 | Materials and Methods for Treating Coagulation Disorders | ARYX THERAPEUTICS, INC. (US) | 2009-03-26 | — | — | US | disclosed |
| US-20080027132-A1 | Materials and Methods For Treating Coagulation Disorders | ARYX THERAPEUTICS (US) | 2008-01-31 | — | — | US | disclosed |
| US-7285671-B2 | Materials and methods for treating coagulation disorders | ARYX THERAPEUTICS (US) | 2007-10-23 | — | — | US | disclosed |
| US-7253208-B2 | Materials and methods for treating coagulation disorders | ARYX THERAPEUTICS (US) | 2007-08-07 | — | — | US | disclosed |
| US-20060287388-A1 | Materials and Methods for Treating Coagulation Disorders | ARYX THERAPEUTICS (US) | 2006-12-21 | — | — | US | disclosed |
| US-20050245603-A1 | Materials and methods for treating coagulation disorders | ESPERO BIOPHARMA, INC. | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245603-A1 | Materials and methods for treating coagulation disorders | F12, F2, SERPINC1 | NQO1 390/4885VKORC1 38/4885MEN1 244/4885 |
| US-20060287388-A1 | Materials and Methods for Treating Coagulation Disorders | F12, F2, SERPINC1 | NQO1 390/4885VKORC1 38/4885MEN1 244/4885 |
| US-20080027132-A1 | Materials and Methods For Treating Coagulation Disorders | F12, F2, SERPINC1 | NQO1 390/4885VKORC1 38/4885MEN1 244/4885 |
| US-20090082430-A1 | Materials and Methods for Treating Coagulation Disorders | F12, F2, SERPINC1 | NQO1 390/4885VKORC1 38/4885MEN1 244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.