Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Anatibant. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 known ✓ | P30411 | 4/20 | 1.00 |
| ▸ | RORC | P51449 | 16/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Anatibant SCHEMBL29403189 | 1.00 | BDKRB2 (1.00) | BDKRB2RORC | |
| Anatibant SCHEMBL6945415 | 1.00 | BDKRB2 (1.00) | BDKRB2RORC | |
| Anatibant SCHEMBL29379305 | 1.00 | BDKRB2 (1.00) | BDKRB2RORC | |
| Anatibant SCHEMBL8045259 | 0.99 | BDKRB2 (0.99) | BDKRB2RORC | |
| Anatibant SCHEMBL29711321 | 0.99 | BDKRB2 (0.98) | BDKRB2RORC | |
| Anatibant SCHEMBL8045426 | 0.99 | BDKRB2 (0.98) | BDKRB2RORC | |
| SCHEMBL6948870 | 0.99 | BDKRB2 (0.98) | BDKRB2RORC | |
| SCHEMBL6950081 | 0.98 | BDKRB2 (0.96) | BDKRB2RORC | |
| Hydrochloric Acid SCHEMBL8040359 | 0.98 | BDKRB2 (0.95) | BDKRB2RORC | |
| SCHEMBL6953304 | 0.98 | BDKRB2 (0.95) | BDKRB2RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016170382-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING A BRADYKININ 2 RECEPTOR ANTAGONIST FOR PREVENTION OR TREATMENT OF IMPAIRED SKIN WOUND HEALING | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2016-10-27 | — | — | WO | disclosed |
| EP-1901775-B1 | KININ ANTAGONISTS FOR TREATING BLADDER DYSFUNCTION | JERINI AG (DE) | 2011-08-24 | — | — | EP | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |