Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Anatibant. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 known ✓ | P30411 | 4/20 | 0.99 |
| ▸ | RORC | P51449 | 16/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Anatibant SCHEMBL29403189 | 0.99 | BDKRB2 (1.00) | BDKRB2RORC | |
| Anatibant SCHEMBL29379305 | 0.99 | BDKRB2 (1.00) | BDKRB2RORC | |
| Anatibant SCHEMBL6945415 | 0.99 | BDKRB2 (1.00) | BDKRB2RORC | |
| Anatibant SCHEMBL1649974 | 0.99 | BDKRB2 (1.00) | BDKRB2RORC | |
| Hydrochloric Acid SCHEMBL8040359 | 0.98 | BDKRB2 (0.95) | BDKRB2RORC | |
| Anatibant SCHEMBL29711321 | 0.98 | BDKRB2 (0.98) | BDKRB2RORC | |
| Anatibant SCHEMBL8045426 | 0.98 | BDKRB2 (0.98) | BDKRB2RORC | |
| SCHEMBL6948870 | 0.98 | BDKRB2 (0.98) | BDKRB2RORC | |
| SCHEMBL6950081 | 0.98 | BDKRB2 (0.96) | BDKRB2RORC | |
| Hydrochloric Acid SCHEMBL8041908 | 0.98 | BDKRB2 (0.94) | BDKRB2RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6063791-A | N-benzenesulfonyl-L-proline derivatives, method for preparing and therapeutic use | FOURNIER INDUSTRIE ET SANTE (FR) | 2000-05-16 | — | — | US | disclosed |