Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK3 | Q9Y572 | 17/20 | 0.64 |
| ▸ | RIPK1 | Q13546 | 17/20 | 0.64 |
| ▸ | BRAF | P15056 | 3/20 | 0.64 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | PDGFA | P04085 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.51 |
| ▸ | TEK | Q02763 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2452621 | 0.94 | RIPK1 (0.70) | RIPK3RIPK1BRAFKDRCHEK1 | |
| SCHEMBL2456245 | 0.85 | BRAF (0.64) | RIPK3RIPK1BRAFKDR | |
| SCHEMBL2452470 | 0.85 | BRAF (0.69) | RIPK3RIPK1BRAFKDR | |
| SCHEMBL2453065 | 0.83 | BRAF (0.67) | RIPK3RIPK1BRAFKDRCHEK1 | |
| SCHEMBL2453182 | 0.83 | RIPK1 (0.80) | RIPK3RIPK1BRAFKDRCHEK1 | |
| SCHEMBL2453162 | 0.81 | BRAF (0.66) | RIPK3RIPK1BRAFKDRCHEK1 | |
| SCHEMBL2851381 | 0.81 | BRAF (0.77) | RIPK3RIPK1BRAFKDRPDGFRB | |
| SCHEMBL2455436 | 0.78 | BRAF (0.64) | RIPK3RIPK1BRAFKDR | |
| SCHEMBL2454632 | 0.78 | BRAF (0.70) | RIPK3RIPK1BRAFKDR | |
| SCHEMBL2452667 | 0.78 | BRAF (0.65) | RIPK3RIPK1BRAFKDRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2399921-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2011-12-28 | — | — | EP | disclosed |