Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Roxatidine Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11399763 | 0.98 | HRH2 (1.00) | HRH2HRH3 | |
| Roxatidine Acetate SCHEMBL29965995 | 0.98 | HRH2 (1.00) | HRH2HRH3 | |
| Roxatidine Acetate SCHEMBL1393 | 0.98 | HRH2 (1.00) | HRH2HRH3 | |
| Roxatidine Acetate SCHEMBL667643 | 0.97 | HRH2 (0.98) | HRH2HRH3 | |
| Roxatidine Acetate SCHEMBL29389759 | 0.97 | HRH2 (0.98) | HRH2HRH3 | |
| SCHEMBL11182082 | 0.97 | HRH2 (0.98) | HRH2HRH3 | |
| Roxatidine Acetate SCHEMBL9084471 | 0.96 | HRH2 (0.96) | HRH2HRH3 | |
| Roxatidine Acetate SCHEMBL482841 | 0.94 | HRH2 (0.93) | HRH2HRH3 | |
| Roxatidine Acetate SCHEMBL2322201 | 0.93 | HRH2 (0.89) | HRH2HRH3 | |
| SCHEMBL11179081 | 0.89 | HRH2 (0.83) | HRH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576778-B1 | TRANSGENIC REPORTER SYSTEM THAT REVEALS EXPRESSION PROFILES AND REGULATION MECHANISMS OF ALTERNATIVE SPLICING IN RODENTS | UNIV KYOTO (JP) | 2017-08-09 | — | — | EP | disclosed |
| US-9273364-B2 | Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in mammalian organisms | KYOTO UNIVERSITY (JP) | 2016-03-01 | — | — | US | disclosed |
| US-20130137099-A1 | TRANSGENIC REPORTER SYSTEM THAT REVEALS EXPRESSION PROFILES AND REGULATION MECHANISMS OF ALTERNATIVE SPLICING IN MAMMALIAN ORGANISMS | KYOTO UNIVERSITY (JP) | 2013-05-30 | — | — | US | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |