SCHEMBL1650806

SCHEMBL1650806

O=C(O)Cc1cc2ccccc2o1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.57
ESR2 Q92731 1/20 0.57
LOXL2 Q9Y4K0 1/20 0.56
FLT3 P36888 1/20 0.52
AGXT P21549 1/20 0.51
PSMB8 P28062 1/20 0.51
PSMB5 P28074 1/20 0.51
TSHR P16473 2/20 0.50
NPC1 O15118 2/20 0.50
RAB9A P51151 2/20 0.50
CA12 O43570 1/20 0.50
CA1 P00915 1/20 0.50
CA3 P07451 1/20 0.50
CA4 P22748 1/20 0.50
CA6 P23280 1/20 0.50
MAOB P27338 1/20 0.50
CA5A P35218 1/20 0.50
CA7 P43166 1/20 0.50
CA9 Q16790 1/20 0.50
GPR35 Q9HC97 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7171559 0.87 ESR1 (0.59) ESR1ESR2LOXL2FLT3AGXT
SCHEMBL8036021 0.84 ESR1 (0.56) ESR1ESR2LOXL2FLT3AGXT
SCHEMBL1259332 0.84 ESR1 (0.56) ESR1ESR2LOXL2FLT3AGXT
SCHEMBL5986670 0.84 LOXL2 (0.59) ESR1ESR2LOXL2FLT3AGXT
SCHEMBL7800851 0.84 ESR1 (0.56) ESR1ESR2LOXL2FLT3AGXT
SCHEMBL7248298 0.82 LOXL2 (0.53) ESR1ESR2LOXL2FLT3AGXT
SCHEMBL11708086 0.82 ESR1 (0.55) ESR1ESR2LOXL2FLT3AGXT
SCHEMBL11101351 0.81 ESR1 (0.54) ESR1ESR2LOXL2FLT3AGXT
SCHEMBL3131445 0.80 ESR1 (0.52) ESR1ESR2LOXL2FLT3AGXT
SCHEMBL22013509 0.80 ESR1 (0.52) ESR1ESR2LOXL2FLT3AGXT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 226 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120131475-A Preparation method and application of high-viscosity full-biological polysaccharide composite gel daily chemical thickener 合肥艾普拉斯环保科技有限公司 2025-06-13 CN claimed
CN-119039727-A Green multiple slow-release biological dispersion glue, preparation method and application 中国石油天然气股份有限公司 2024-11-29 CN claimed
CN-112939748-A Method for preparing deuterated compound through decarboxylation and deuteration of carboxylic acid 中国科学院大连化学物理研究所 2021-06-11 CN claimed
EP-1904502-B1 ANTIARRHYTHMIC PRECURSOR COMPOUNDS, METHODS OF SYNTHESIS AND METHODS OF USE ARYX THERAPEUTICS INC (US) 2009-10-21 EP claimed
US-7498449-B2 Antiarrhythmic precursor compounds, methods of synthesis and methods of use ARYX THERAPEUTICS (US) 2009-03-03 US claimed
EP-1904502-A2 ANTIARRHYTHMIC PRECURSOR COMPOUNDS, METHODS OF SYNTHESIS AND METHODS OF USE Aryx Therapeutics, Inc. (US) 2008-04-02 EP claimed
US-20070060640-A1 Antiarrhythmic Precursor Compounds, Methods Of Synthesis And Methods Of Use ARYX THERAPEUTICS (US) 2007-03-15 US claimed
WO-2007011835-A2 ANTIARRHYTHMIC PRECURSOR COMPOUNDS, METHODS OF SYNTHESIS AND METHODS OF USE ARYX THERAPEUTICS, INC. (US) 2007-01-25 WO claimed
EP-0446809-A1 New process for the synthesis of 5-acyloxy and 5-alkoxy-2,3-dihydro-4,6,7-trimethyl-2-(RS)-benzofuranacetic acids BIOMEDICA FOSCAMA INDUSTRIA CHIMICO-FARMACEUTICA S.P.A. (IT) 1991-09-18 EP claimed
JP-52010259-A None JP disclosed
JP-52010260-A None JP disclosed
JP-52010257-A None JP disclosed
JP-52010258-A None JP disclosed
US-20250290137-A1 SUBSTITUTED COUMARIN DYES AND USES AS FLUORESCENT LABELS ILLUMINA CAMBRIDGE LIMITED (GB) 2025-09-18 US disclosed
US-4126625-A ANTIPHLOGISTIC, ANALGESIC KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) 1978-11-21 US disclosed
US-4104396-A NEUROLEPTIC, ANALGESIC CIBA-GEIGY CORPORATION (US) 1978-08-01 US disclosed
JP-S5210259-A PREPARATION OF BENZOFURAN DERIVATIVES KYOWA HAKKO KOGYO CO LTD 1977-01-26 JP disclosed
JP-S5210257-A PREPARATION OF BENZOFURAN DERIVATIVES KYOWA HAKKO KOGYO CO LTD 1977-01-26 JP disclosed
JP-S5210260-A PREPARATION OF BENZOFURAN DERIVATIVES KYOWA HAKKO KOGYO CO LTD 1977-01-26 JP disclosed
JP-S5210258-A PREPARATION OF BENZOFURAN DERIVATIVES KYOWA HAKKO KOGYO CO LTD 1977-01-26 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250290137-A1 SUBSTITUTED COUMARIN DYES AND USES AS FLUORESCENT LABELS FBL, DUT, PHAX ESR1 1486/4885ESR2 2668/4885LOXL2 2375/4885
US-20070060640-A1 Antiarrhythmic Precursor Compounds, Methods Of Synthesis And Methods Of Use SCN11A, SCN10A, CYP4F11 ESR1 1700/4885ESR2 1069/4885LOXL2 4823/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.