Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 1/20 | 0.56 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.56 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.56 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.39 |
| ▸ | COMT | P21964 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30842108 | 0.87 | NAPRT (0.44) | EP300KAT2BKAT8TTRAURKA | |
| SCHEMBL20836182 | 0.87 | NAPRT (0.44) | EP300KAT2BKAT8TTRAURKA | |
| SCHEMBL8031733 | 0.85 | NAPRT (0.42) | EP300KAT2BKAT8TTRAURKA | |
| SCHEMBL1491302 | 0.79 | POLB (0.38) | TTRCYP1A2COMTNAPRTCSNK1A1 | |
| SCHEMBL5894746 | 0.77 | AXL (0.72) | EP300KAT2BKAT8AXLCYP1A2 | |
| SCHEMBL5355239 | 0.76 | AXL (0.51) | TTRAXLCYP1A2COMTNAPRT | |
| SCHEMBL30987405 | 0.76 | AXL (0.51) | TTRAXLCYP1A2COMTNAPRT | |
| SCHEMBL1525888 | 0.76 | TTR (0.78) | EP300KAT2BKAT8TTRAURKA | |
| SCHEMBL4808842 | 0.76 | CA12 (0.44) | EP300KAT2BKAT8TTRNAPRT | |
| SCHEMBL29516385 | 0.76 | TTR (0.78) | EP300KAT2BKAT8TTRAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110294789-A1 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | AMNESTIX, INC. | 2011-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294789-A1 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | ROCK1, IRAK1, ROCK2 | EP300 799/4885KAT2B 1656/4885KAT8 2107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.