Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | COMT | P21964 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30842108 | 0.87 | NAPRT (0.44) | COMTNAPRTALDH1A1CYP1A2ALOX15 | |
| SCHEMBL20836182 | 0.87 | NAPRT (0.44) | COMTNAPRTALDH1A1CYP1A2ALOX15 | |
| SCHEMBL8031733 | 0.85 | NAPRT (0.42) | COMTNAPRTALDH1A1CYP1A2ALOX15 | |
| SCHEMBL29469844 | 0.83 | CSNK1A1 (0.38) | ALDH1A1SIRT3TDP1HIPK2SLC22A12 | |
| SCHEMBL16508188 | 0.79 | EP300 (0.56) | POLBCOMTNAPRTALDH1A1CYP1A2 | |
| SCHEMBL1491306 | 0.79 | HASPIN (0.37) | COMTNAPRTALDH1A1CYP1A2ALOX15 | |
| SCHEMBL812489 | 0.77 | CYP1A2 (0.46) | POLBRECQLALDH1A1CYP1A2HIF1A | |
| SCHEMBL5355239 | 0.76 | AXL (0.51) | COMTNAPRTALDH1A1CYP1A2ALOX15 | |
| SCHEMBL30987405 | 0.76 | AXL (0.51) | COMTNAPRTALDH1A1CYP1A2ALOX15 | |
| SCHEMBL2563881 | 0.76 | TDP1 (0.46) | POLBRECQLESR2NAPRTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102316737-A | Compounds for RHO kinase inhibition and for improving learning and memory | AMNESTIX INC | 2012-01-11 | — | — | CN | disclosed |
| US-20110294789-A1 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | AMNESTIX, INC. | 2011-12-01 | — | — | US | disclosed |
| US-20110294789-A1 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | AMNESTIX, INC. | 2011-12-01 | — | — | US | disclosed |
| EP-2296472-A1 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | Amnestix, Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009151845-A9 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | AMNESTIX, INC. (US) | 2010-01-28 | — | — | WO | disclosed |
| WO-2009151845-A1 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | AMNESTIX, INC. (US) | 2009-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294789-A1 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | ROCK1, IRAK1, ROCK2 | POLB 4324/4885RECQL 2720/4885ESR2 3398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.