Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16511789 | 0.99 | HDAC1 (0.55) | HDAC1CTSBCTSSCTSKCTSF | |
| SCHEMBL17921133 | 0.89 | HDAC1 (0.52) | HDAC1CTSBCTSSCTSKCTSF | |
| SCHEMBL17921141 | 0.88 | HDAC1 (0.51) | HDAC1CTSBCTSSCTSKCTSF | |
| SCHEMBL16511766 | 0.86 | NAMPT (0.44) | HDAC1KDM4EALDH1A1GAALMNA | |
| SCHEMBL16512631 | 0.86 | RXFP1 (0.48) | HDAC1KDM4EALDH1A1GAAL3MBTL1 | |
| SCHEMBL16511408 | 0.82 | CTSB (0.47) | HDAC1CTSBCTSSKDM4EALDH1A1 | |
| SCHEMBL16512687 | 0.79 | HDAC1 (0.54) | HDAC1CTSBCTSSCTSKCTSF | |
| SCHEMBL16511441 | 0.79 | HDAC1 (0.44) | HDAC1CTSBCTSSCTSKCTSF | |
| SCHEMBL16511341 | 0.79 | HDAC1 (0.44) | HDAC1CTSBCTSSCTSKCTSF | |
| SCHEMBL16512634 | 0.78 | HDAC1 (0.43) | HDAC1CTSBCTSSCTSKCTSF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10189786-B2 | Antibacterial compounds | DUKE UNIVERSITY (US) | 2019-01-29 | — | — | US | disclosed |
| US-20160200673-A1 | Antibacterial Compounds | DUKE UNIVERSITY | 2016-07-14 | — | — | US | disclosed |
| US-20160200673-A1 | Antibacterial Compounds | DUKE UNIVERSITY | 2016-07-14 | — | — | US | disclosed |
| WO-2015024021-A2 | ANTIBACTERIAL COMPOUNDS | DUKE UNIVERSITY (US) | 2015-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10189786-B2 | Antibacterial compounds | Q6ZSR9, MRPL21, XDH | HDAC1 754/4885CTSB 718/4885CTSS 627/4885 |
| US-20160200673-A1 | Antibacterial Compounds | Q6ZSR9, MRPL21, XDH | HDAC1 754/4885CTSB 718/4885CTSS 627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.