Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 8/20 | 0.53 |
| ▸ | JAK2 | O60674 | 3/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | JUN | P05412 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.46 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.46 |
| ▸ | CTSC | P53634 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | WEE1 | P30291 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16513535 | 0.88 | SYK (0.56) | BRD4JUNMAPK10MAPK8NTRK1 | |
| SCHEMBL16514265 | 0.87 | WEE1 (0.53) | BRD4JAK2JUNMAPK10MAPK8 | |
| SCHEMBL29847672 | 0.87 | WEE1 (0.53) | BRD4JAK2JUNMAPK10MAPK8 | |
| SCHEMBL16513575 | 0.86 | CCND3 (0.57) | BRD4JAK2EGFRJAK3FGFR2 | |
| SCHEMBL29576058 | 0.82 | JAK2 (0.63) | BRD4JAK2EGFRJUNMAPK10 | |
| SCHEMBL16823053 | 0.82 | JAK2 (0.63) | BRD4JAK2EGFRJUNMAPK10 | |
| SCHEMBL16514312 | 0.78 | JUN (0.48) | JUNMAPK10MAPK8FGFR2SRC | |
| SCHEMBL16514379 | 0.77 | JUN (0.62) | JUNMAPK10MAPK8 | |
| SCHEMBL29848014 | 0.77 | JUN (0.62) | JUNMAPK10MAPK8 | |
| SCHEMBL29847505 | 0.77 | WEE1 (0.55) | BRD4JAK2JUNMAPK10MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3035936-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | NeuPharma, Inc. (US) | 2016-06-29 | — | — | EP | disclosed |
| WO-2015027222-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | NEUPHARMA, INC. (US) | 2015-02-26 | — | — | WO | disclosed |