Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.47 |
| ▸ | BTK | Q06187 | 3/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 4/20 | 0.44 |
| ▸ | JUN | P05412 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 3/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29848065 | 0.93 | JUN (0.48) | EGFRBTKJAK2FGFR2SYK | |
| SCHEMBL16514508 | 0.93 | JUN (0.48) | EGFRBTKJAK2FGFR2SYK | |
| SCHEMBL29847734 | 0.88 | JUN (0.51) | EGFRBTKFGFR2SYKJUN | |
| SCHEMBL16513858 | 0.88 | JUN (0.51) | EGFRBTKFGFR2SYKJUN | |
| SCHEMBL29847956 | 0.88 | EGFR (0.53) | EGFRJAK2FGFR2JAK3FGFR1 | |
| SCHEMBL16513782 | 0.88 | EGFR (0.53) | EGFRJAK2FGFR2JAK3FGFR1 | |
| SCHEMBL16515169 | 0.87 | EGFR (0.45) | EGFRBTKJAK2FGFR2SYK | |
| SCHEMBL16513571 | 0.87 | JUN (0.48) | EGFRBTKFGFR2SYKJUN | |
| SCHEMBL29847725 | 0.87 | JUN (0.48) | EGFRBTKFGFR2SYKJUN | |
| SCHEMBL16514888 | 0.85 | SYK (0.47) | EGFRBTKSYKJUNMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3035936-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | NeuPharma, Inc. (US) | 2016-06-29 | — | — | EP | claimed |
| WO-2015027222-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | NEUPHARMA, INC. (US) | 2015-02-26 | — | — | WO | claimed |