Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 6/20 | 0.49 |
| ▸ | BRD4 | O60885 | 5/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.48 |
| ▸ | CDK4 | P11802 | 6/20 | 0.48 |
| ▸ | CCND1 | P24385 | 6/20 | 0.48 |
| ▸ | CDK2 | P24941 | 6/20 | 0.48 |
| ▸ | CDK1 | P06493 | 3/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | WEE1 | P30291 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | BRD2 | P25440 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.47 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16513782 | 1.00 | EGFR (0.53) | EGFRJAK2BRD4FGFR2CDK4 | |
| SCHEMBL29847882 | 0.90 | WEE1 (0.43) | EGFRJAK2BRD4FGFR2CDK4 | |
| SCHEMBL16513790 | 0.90 | WEE1 (0.43) | EGFRJAK2BRD4FGFR2CDK4 | |
| SCHEMBL16514445 | 0.88 | EGFR (0.68) | EGFRJAK2BRD4FGFR2CDK4 | |
| SCHEMBL29847104 | 0.88 | EGFR (0.68) | EGFRJAK2BRD4FGFR2CDK4 | |
| SCHEMBL16515355 | 0.88 | EGFR (0.47) | EGFRJAK2FGFR2FGFR1KDR | |
| SCHEMBL16514961 | 0.87 | KCNH2 (0.53) | JAK2BRD4FGFR2CDK4CCND1 | |
| SCHEMBL29847672 | 0.87 | WEE1 (0.53) | JAK2BRD4CDK4CCND1CDK2 | |
| SCHEMBL16514265 | 0.87 | WEE1 (0.53) | JAK2BRD4CDK4CCND1CDK2 | |
| SCHEMBL16514117 | 0.86 | EGFR (0.53) | EGFRJAK2BRD4FGFR2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109851617-B | Chemical entities, compositions, and methods | 润新生物公司 | 2022-08-16 | — | — | CN | disclosed |