Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 14/20 | 0.68 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.45 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | IL1RN | P18510 | 1/20 | 0.40 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16518262 | 0.89 | HTR5A (0.71) | HTR5A | |
| SCHEMBL16518251 | 0.85 | HTR5A (0.69) | HTR5AHTR7HTR2B | |
| SCHEMBL16518267 | 0.83 | HTR5A (0.76) | HTR5A | |
| SCHEMBL16518258 | 0.82 | HTR5A (0.67) | HTR5A | |
| SCHEMBL16518254 | 0.82 | HTR5A (0.78) | HTR5A | |
| SCHEMBL16518255 | 0.81 | HTR5A (1.00) | HTR5A | |
| SCHEMBL16518309 | 0.81 | HTR5A (0.59) | HTR5AABHD6 | |
| SCHEMBL11495251 | 0.80 | NOTUM (0.60) | HTR5AABHD6UCHL1 | |
| SCHEMBL16518250 | 0.80 | HTR5A (0.74) | HTR5A | |
| SCHEMBL16518271 | 0.79 | HTR5A (0.70) | HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |