Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.60 |
| ▸ | PTAFR | P25105 | 1/20 | 0.50 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.49 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | HTR5A | P47898 | 1/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16518191 | 0.82 | UCHL1 (0.62) | ABHD6UCHL1PTGDR2 | |
| SCHEMBL14591318 | 0.80 | NOTUM (0.65) | NOTUMPTAFRCREBBPMAPTLMNA | |
| SCHEMBL16518260 | 0.80 | HTR5A (0.68) | ABHD6UCHL1HTR5A | |
| SCHEMBL17197242 | 0.79 | NOTUM (0.63) | NOTUMPTAFRABHD6CREBBPMAPT | |
| SCHEMBL30261507 | 0.78 | NOTUM (0.58) | NOTUMPTAFRCREBBPMAPTLMNA | |
| SCHEMBL14287493 | 0.78 | NOTUM (0.47) | NOTUMPTAFRABHD6CREBBPMAPT | |
| SCHEMBL2252826 | 0.78 | NOTUM (0.61) | NOTUMPTAFRABHD6CREBBPMAPT | |
| SCHEMBL12269322 | 0.78 | NOTUM (0.61) | NOTUMPTAFRABHD6CREBBPMAPT | |
| SCHEMBL9270908 | 0.78 | NOTUM (0.61) | NOTUMPTAFRMAPTLMNABAZ2B | |
| SCHEMBL11488388 | 0.77 | MAOA (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4220778-A | ANTIARRHYTHMIC, ANTIMICROBIAL AND CENTRAL NERVOUS SYSTEM ACTIVITY | G. D. SEARLE & CO. (US) | 1980-09-02 | — | — | US | disclosed |