Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | RPS6KB2 | Q9UBS0 | 3/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL41299 | 0.77 | KDM4E (0.43) | NPC1RAB9AATMRPS6KB2TDO2 | |
| SCHEMBL2608126 | 0.77 | KDM4E (0.47) | NPC1RAB9AATMRPS6KB2TDO2 | |
| SCHEMBL16658931 | 0.75 | RAB9A (0.39) | NPC1RAB9AATMRPS6KB2TDO2 | |
| Benzo[1,2,5]Thiadiazole SCHEMBL27923229 | 0.75 | KDM4E (0.44) | NPC1RAB9AATMRPS6KB2ALDH1A1 | |
| SCHEMBL14486673 | 0.75 | KDM4E (0.38) | NPC1RAB9AATMRPS6KB2CHEK1 | |
| SCHEMBL28388125 | 0.73 | GRIN2D (0.35) | NPC1RAB9ARPS6KB2ALDH1A1KDM4E | |
| SCHEMBL23724046 | 0.71 | RPS6KB2 (0.68) | NPC1RAB9AATMRPS6KB2DHFR | |
| SCHEMBL12587621 | 0.71 | DPP4 (0.40) | NPC1RAB9AATMTDO2ALDH1A1 | |
| SCHEMBL28696640 | 0.71 | RPS6KB2 (0.35) | NPC1RAB9AATMRPS6KB2ALDH1A1 | |
| SCHEMBL28380043 | 0.70 | RPS6KB2 (0.47) | NPC1RAB9AATMRPS6KB2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9209409-B2 | Naphthobisthiadiazole derivative | NATIONAL UNIVERSITY OF CORPORATION HIROSHIMA UNIVERSITY (JP) | 2015-12-08 | — | — | US | disclosed |
| US-20150112081-A1 | NAPHTHOBISTHIADIAZOLE DERIVATIVE | NATIONAL UNIVERSITY OF CORPORATION HIROSHIMA UNIVERSITY (JP) | 2015-04-23 | — | — | US | disclosed |
| EP-2842958-A1 | NAPHTHOBISTHIADIAZOLE DERIVATIVE | National University of Corporation Hiroshima University (JP) | 2015-03-04 | — | — | EP | disclosed |