Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1651727 | 0.87 | NPC1 (0.32) | MAPK14ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL12777822 | 0.83 | CYP1A2 (0.44) | L3MBTL1GRIK2NPSR1HTTMAPK9 | |
| SCHEMBL1653145 | 0.80 | BRD4 (0.48) | L3MBTL1GRIK2ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL1652825 | 0.74 | KDM4E (0.40) | L3MBTL1GRIK2HTTNCOA1NCOA3 | |
| SCHEMBL1654665 | 0.67 | MAP2 (0.37) | L3MBTL1NPSR1RXFP1KDM4EALDH1A1 | |
| SCHEMBL30336533 | 0.67 | ALDH1A1 (0.59) | L3MBTL1NPSR1HTTSMN1; SMN2KDM4E | |
| SCHEMBL28610662 | 0.67 | ALDH1A1 (0.59) | L3MBTL1NPSR1HTTSMN1; SMN2KDM4E | |
| SCHEMBL1653307 | 0.67 | MAPT (0.33) | L3MBTL1NPSR1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1651655 | 0.67 | BRD4 (0.43) | ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1652576 | 0.66 | PTPN1 (0.33) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486010-B1 | ESTROGEN RECEPTOR LIGANDS | KARO PHARMA AB (SE) | 2019-06-12 | — | — | EP | disclosed |
| EP-2486010-B1 | ESTROGEN RECEPTOR LIGANDS | KARO PHARMA AB (SE) | 2019-06-12 | — | — | EP | disclosed |
| US-8710243-B2 | Estrogen receptor ligands | KARO BIO AB (SE) | 2014-04-29 | — | — | US | disclosed |
| EP-2486010-A2 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2012-08-15 | — | — | EP | disclosed |
| US-20120202861-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2012-08-09 | — | — | US | disclosed |
| US-20120202861-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2012-08-09 | — | — | US | disclosed |
| US-20120202861-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2012-08-09 | — | — | US | disclosed |
| WO-2011042473-A2 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202861-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | ESR1, ESRRA, GPER1 | L3MBTL1 2510/4885GRIK2 1058/4885NPSR1 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.