Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Phthalimide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.94 |
| ▸ | CASP7 | P55210 | 3/20 | 0.75 |
| ▸ | CASP3 | P42574 | 2/20 | 0.75 |
| ▸ | CASP6 | P55212 | 2/20 | 0.75 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.75 |
| ▸ | CASP2 | P42575 | 1/20 | 0.75 |
| ▸ | PARP1 | P09874 | 4/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
| ▸ | FER | P16591 | 1/20 | 0.56 |
| ▸ | LTK | P29376 | 1/20 | 0.56 |
| ▸ | CDK8 | P49336 | 1/20 | 0.56 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 5/20 | 0.50 |
| ▸ | MAOB | P27338 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalimide SCHEMBL4322817 | 1.00 | GSK3B (0.94) | GSK3BCASP7CASP3CASP6CASP8 | |
| Phthalimide SCHEMBL14764095 | 0.97 | GSK3B (0.88) | GSK3BCASP7CASP3CASP6CASP8 | |
| Phthalimide SCHEMBL10192661 | 0.97 | GSK3B (1.00) | GSK3BCASP7CASP3CASP6CASP8 | |
| Phthalimide SCHEMBL30125197 | 0.97 | GSK3B (1.00) | GSK3BCASP7CASP3CASP6CASP8 | |
| Phthalimide SCHEMBL28226707 | 0.97 | GSK3B (1.00) | GSK3BCASP7CASP3CASP6CASP8 | |
| Phthalimide SCHEMBL7771670 | 0.97 | GSK3B (1.00) | GSK3BCASP7CASP3CASP6CASP8 | |
| Phthalimide SCHEMBL29366030 | 0.97 | GSK3B (1.00) | GSK3BCASP7CASP3CASP6CASP8 | |
| Phthalimide SCHEMBL64 | 0.97 | GSK3B (1.00) | GSK3BCASP7CASP3CASP6CASP8 | |
| Phthalimide SCHEMBL11040503 | 0.97 | GSK3B (1.00) | GSK3BCASP7CASP3CASP6CASP8 | |
| Phthalimide SCHEMBL5742518 | 0.94 | GSK3B (0.94) | GSK3BCASP7CASP3CASP6CASP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116444476-B | Preparation method of polyketone anticancer natural product Naphthospironone A | 南开大学 | 2024-08-09 | — | — | CN | claimed |
| CN-106336349-B | Bromo trifluoromethoxy compound and its synthetic method | 南京优氟医药科技有限公司 | 2019-08-02 | — | — | CN | claimed |
| CN-109233131-A | A kind of flame retardant type high durable ASA co-extrusion materials | 浙江宏博新型建材有限公司 | 2019-01-18 | — | — | CN | claimed |
| CN-109134460-A | A kind of synthetic method of B-carboline class compound | 南开大学 | 2019-01-04 | — | — | CN | claimed |
| CN-109020814-A | A kind of polysubstituted 10- hydroxyl is luxuriant and rich with fragrance and its derivative and its synthetic method | 南开大学 | 2018-12-18 | — | — | CN | claimed |
| CN-108117645-A | The poly- fragrant acid imide manufacturing method of one kind and its process units | 梅雪 | 2018-06-05 | — | — | CN | claimed |
| CN-106336349-A | Bromotrifluoromethoxy compound and synthetic method thereof | 南开大学 | 2017-01-18 | — | — | CN | claimed |
| CN-101887773-B | Insulated cable, component for control system and manufacturing method of component for control system | NGK SPARK PLUG CO | 2014-08-06 | — | — | CN | claimed |
| CN-101887773-A | Insulated cable, control system are with parts and control system member manufacturing method | NGK SPARK PLUG CO | 2010-11-17 | — | — | CN | claimed |
| CN-116444476-B | Preparation method of polyketone anticancer natural product Naphthospironone A | 南开大学 | 2024-08-09 | — | — | CN | disclosed |
| CN-116444476-A | Preparation method of polyketone anticancer natural product Naphthospironone A | 南开大学 | 2023-07-18 | — | — | CN | disclosed |
| CN-106795105-B | Novel method for producing azodicarbonamide | 杭州海虹精细化工有限公司 | 2019-11-15 | — | — | CN | disclosed |
| CN-110446725-A | The manufacturing method of polymer, the compound and polymer for causing group containing free radical polymerization | DAINICHISEIKA COLOR CHEM | 2019-11-12 | — | — | CN | disclosed |
| CN-110204525-A | Novel fluoro unsaturated cyclic carbonic ester and its manufacturing method | 大金工业株式会社 | 2019-09-06 | — | — | CN | disclosed |
| EP-2611860-A1 | EXPANDED POLYOLEFIN CONTAINING POWDERED ACTIVATED CARBON | Kaneka Belgium N.V. (BE) | 2013-07-10 | — | — | EP | disclosed |
| US-20130158141-A1 | EXPANDED POLYOLEFIN CONTAINING POWDERED ACTIVATED CARBON | KANEKA BELGIUM N.V. (BE) | 2013-06-20 | — | — | US | disclosed |
| WO-2012056320-A1 | EXPANDED POLYOLEFIN CONTAINING POWDERED ACTIVATED CARBON | KANEKA BELGIUM N.V. (BE) | 2012-05-03 | — | — | WO | disclosed |
| WO-2012028953-A1 | EXPANDED POLYOLEFIN CONTAINING POWDERED ACTIVATED CARBON | KANEKA BELGIUM N.V. (BE) | 2012-03-08 | — | — | WO | disclosed |
| CN-101887773-A | Insulated cable, control system are with parts and control system member manufacturing method | NGK SPARK PLUG CO | 2010-11-17 | — | — | CN | disclosed |
| US-5468424-A | Mixture of powders or particles of antimony oxide and lead stabilizer with plasticizers | AMSPEC CHEMICAL CO., INC. (US) | 1995-11-21 | — | — | US | disclosed |