Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ALPL | P05186 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 5/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
| ▸ | ALPI | P09923 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14138506 | 0.91 | KDM4E (0.62) | SNCAKDM4EALPLMAPTLMNA | |
| SCHEMBL10057827 | 0.80 | SNCA (0.77) | SNCAKDM4EALPLMAPTLMNA | |
| SCHEMBL6250827 | 0.78 | SNCA (0.56) | SNCAKDM4EALPLMAPTLMNA | |
| SCHEMBL16539443 | 0.78 | MAPT (0.55) | KDM4EALPLMAPTLMNAMEN1 | |
| SCHEMBL16539440 | 0.78 | MAPT (0.55) | KDM4EALPLMAPTLMNAMEN1 | |
| SCHEMBL31703271 | 0.77 | DCUN1D1 (0.51) | SNCAKDM4EALPLMAPTLMNA | |
| SCHEMBL16547817 | 0.76 | MAPT (0.53) | SNCAKDM4EALPLMAPTLMNA | |
| SCHEMBL17924185 | 0.76 | MAPT (0.53) | SNCAKDM4EALPLMAPTLMNA | |
| SCHEMBL18671583 | 0.75 | DUSP3 (0.48) | KDM4EALPLMAPTLMNAMEN1 | |
| SCHEMBL17279918 | 0.75 | SNCA (0.82) | SNCAKDM4EALPLMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2944635-B1 | PYRAZOLE LINKED BENZIMIDAZOLE CONJUGATES AND A PROCESS FOR PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2018-11-28 | — | — | EP | disclosed |
| EP-3039013-B1 | PYRAZOLOCHALCONES AS POTENTIAL ANTICANCER AGENTS | COUNCIL SCIENT IND RES (IN) | 2018-09-12 | — | — | EP | disclosed |
| US-9951049-B2 | Pyrazole linked benzimidazole conjugates and a process for preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2018-04-24 | — | — | US | disclosed |
| US-9604933-B2 | Pyrazolochalcones as potential anticancer agents | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-03-28 | — | — | US | disclosed |
| US-20160207888-A1 | PYRAZOLOCHALCONES AS POTENTIAL ANTICANCER AGENTS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-07-21 | — | — | US | disclosed |
| EP-3039013-A1 | PYRAZOLOCHALCONES AS POTENTIAL ANTICANCER AGENTS | Council of Scientific and Industrial Research (IN) | 2016-07-06 | — | — | EP | disclosed |
| US-20150329527-A1 | PYRAZOLE LINKED BENZIMIDAZOLE CONJUGATES AND A PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-11-19 | — | — | US | disclosed |
| EP-2944635-A1 | PYRAZOLE LINKED BENZIMIDAZOLE CONJUGATES AND A PROCESS FOR PREPARATION THEREOF | Council of Scientific & Industrial Research (IN) | 2015-11-18 | — | — | EP | disclosed |
| WO-2015029051-A1 | PYRAZOLOCHALCONES AS POTENTIAL ANTICANCER AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2015-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207888-A1 | PYRAZOLOCHALCONES AS POTENTIAL ANTICANCER AGENTS | HCCS, CCNE2, FOXO3 | SNCA 3499/4885KDM4E 1002/4885ALPL 4647/4885 |
| US-20150329527-A1 | PYRAZOLE LINKED BENZIMIDAZOLE CONJUGATES AND A PROCESS FOR PREPARATION THEREOF | BRDT, MCL1, MGST3 | SNCA 3280/4885KDM4E 1744/4885ALPL 3575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.