Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 17/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.50 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.50 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2064476 | 0.82 | HTR2A (0.65) | — | |
| SCHEMBL2064347 | 0.80 | KDM4C (0.51) | RAB9A | |
| SCHEMBL885849 | 0.76 | HTR2A (0.61) | — | |
| SCHEMBL3080448 | 0.75 | HTR2A (0.62) | NPC1RAB9A | |
| SCHEMBL29573491 | 0.74 | HTR2A (0.73) | — | |
| SCHEMBL1166246 | 0.74 | HTR2A (0.73) | — | |
| SCHEMBL15095491 | 0.74 | ALDH1A1 (0.50) | — | |
| SCHEMBL3093462 | 0.73 | HTR2A (0.70) | NPC1RAB9A | |
| SCHEMBL19442038 | 0.72 | ALDH1A1 (0.46) | — | |
| SCHEMBL3076492 | 0.70 | ALDH1A1 (0.49) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018371-B1 | PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2015-03-04 | — | — | EP | disclosed |