SCHEMBL16553576

SCHEMBL16553576

CC(=O)Oc1ccc(OC/C=C(\c2ccc(F)cc2)c2ccc(C#CCN3CCOCC3)cc2)cc1C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 2/20 0.44
PPARD Q03181 7/20 0.44
PPARG P37231 3/20 0.41
PPARA Q07869 3/20 0.41
HPGD P15428 2/20 0.36
LMNA P02545 1/20 0.36
PKM P14618 1/20 0.36
HTT P42858 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
KDM4E B2RXH2 2/20 0.35
ALDH1A1 P00352 2/20 0.35
TDP1 Q9NUW8 1/20 0.35
MMP13 P45452 2/20 0.35
FKBP1A P62942 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
NPC1 O15118 1/20 0.35
GAA P10253 1/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16553795 0.94 PPARD (0.45) MAPK14PPARDPPARGPPARAHPGD
SCHEMBL28662240 0.92 PPARD (0.43) MAPK14PPARDPPARGPPARAHPGD
SCHEMBL22829501 0.92 KDM4E (0.45) MAPK14PPARDPPARGPPARAHPGD
Mavodelpar SCHEMBL1746564 0.91 PPARD (0.55) MAPK14PPARDPPARGPPARA
Mavodelpar SCHEMBL1746569 0.91 PPARD (0.55) MAPK14PPARDPPARGPPARA
Mavodelpar SCHEMBL1746567 0.91 PPARD (0.55) MAPK14PPARDPPARGPPARA
Mavodelpar SCHEMBL22323854 0.90 PPARD (0.54) MAPK14PPARDPPARGPPARA
Mavodelpar SCHEMBL18197418 0.90 PPARD (0.54) MAPK14PPARDPPARGPPARA
Mavodelpar SCHEMBL18197414 0.90 PPARD (0.54) MAPK14PPARDPPARGPPARA
SCHEMBL22340236 0.90 PPARD (0.44) MAPK14PPARDPPARGPPARAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3043789-A1 USE OF A PPAR-DELTA AGONIST FOR TREATING MUSCLE ATROPHY vTv Therapeutics LLC (US) 2016-07-20 EP claimed
WO-2015035171-A1 USE OF A PPAR-DELTA AGONIST FOR TREATING MUSCLE ATROPHY HIGH POINT PHARMACEUTICALS, LLC (US) 2015-03-12 WO claimed
EP-3927718-A1 USE OF PPAR-DELTA AGONISTS IN THE TREATMENT OF MITOCHONDRIAL MYOPATHY Reneo Pharmaceuticals, Inc. (US) 2021-12-29 EP disclosed
EP-3043789-A1 USE OF A PPAR-DELTA AGONIST FOR TREATING MUSCLE ATROPHY vTv Therapeutics LLC (US) 2016-07-20 EP disclosed
WO-2015035171-A1 USE OF A PPAR-DELTA AGONIST FOR TREATING MUSCLE ATROPHY HIGH POINT PHARMACEUTICALS, LLC (US) 2015-03-12 WO disclosed