Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | ATR | Q13535 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15612499 | 0.84 | TSHR (0.36) | TSHRAKR1C3ALDH1A1NPC1RAB9A | |
| SCHEMBL4484310 | 0.82 | ALDH1A1 (0.37) | TSHRALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2147869 | 0.82 | ALDH1A1 (0.37) | TSHRALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15415643 | 0.81 | TSHR (0.40) | TSHRAKR1C3ALDH1A1NPC1RAB9A | |
| SCHEMBL19127686 | 0.80 | ABL1 (0.38) | TSHRALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL745011 | 0.74 | SMN1; SMN2 (0.35) | TSHRAKR1C3ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL29563888 | 0.73 | HTR1A (0.34) | PDE2APDE10A | |
| SCHEMBL15611917 | 0.70 | ALDH1A1 (0.36) | TSHRALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15168507 | 0.70 | ALDH1A1 (0.34) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2483006 | 0.70 | ALDH1A1 (0.37) | TSHRALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015034729-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-03-12 | — | — | WO | disclosed |