Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ADH1B | P00325 | 1/20 | 0.39 |
| ▸ | ADH1C | P00326 | 1/20 | 0.39 |
| ▸ | ADH1A | P07327 | 1/20 | 0.39 |
| ▸ | ADH4 | P08319 | 1/20 | 0.39 |
| ▸ | ADH7 | P40394 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.38 |
| ▸ | FDPS | P14324 | 3/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL214294 | 0.84 | MAPT (0.42) | MAPTADH1BADH1CADH1AADH4 | |
| SCHEMBL10436066 | 0.83 | MAPT (0.41) | MAPTADH1BADH1CADH1AADH4 | |
| SCHEMBL7198180 | 0.81 | MAPT (0.39) | MAPTADH1BADH1CADH1AADH4 | |
| SCHEMBL18115130 | 0.81 | MAPT (0.39) | MAPTADH1BADH1CADH1AADH4 | |
| SCHEMBL8411270 | 0.80 | MAPT (0.42) | MAPTADH1BADH1CADH1AADH4 | |
| SCHEMBL10424212 | 0.78 | MAPT (0.41) | MAPTADH1BADH1CADH1AADH4 | |
| SCHEMBL1409547 | 0.77 | OPRM1 (0.42) | MAPTADH1BADH1CADH1AADH4 | |
| SCHEMBL10380231 | 0.77 | SPHK1 (0.50) | MAPTFFAR1FFAR4GPR84SPHK1 | |
| SCHEMBL10380788 | 0.77 | SPHK1 (0.50) | MAPTFFAR1FFAR4GPR84SPHK1 | |
| SCHEMBL7180270 | 0.75 | GPR84 (0.44) | MAPTFFAR1FFAR4GPR84FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105764902-B | Spiro-compound as tryptophan hydroxylase inhibitor | 卡罗斯制药公司 | 2019-02-15 | — | — | CN | disclosed |
| EP-3041842-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | Karos Pharmaceuticals, Inc. (US) | 2016-07-13 | — | — | EP | disclosed |
| WO-2015035113-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2015-03-12 | — | — | WO | disclosed |