Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 2/20 | 0.52 |
| ▸ | HTR7 | P34969 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28631444 | 0.92 | KDM4E (0.58) | KDM4ECYP1A2CYP2D6ALOX15TDP1 | |
| SCHEMBL30921653 | 0.92 | KDM4E (0.58) | KDM4ECYP1A2CYP2D6ALOX15TDP1 | |
| Cgs-19281A SCHEMBL2930783 | 0.81 | KDM4E (0.58) | KDM4ECYP1A2CYP2D6ALOX15TDP1 | |
| Cgs-19281A SCHEMBL29769895 | 0.81 | KDM4E (0.58) | KDM4ECYP1A2CYP2D6ALOX15TDP1 | |
| SCHEMBL4279959 | 0.74 | LMNA (0.67) | KDM4ECYP1A2CYP2D6ALOX15TDP1 | |
| SCHEMBL4286367 | 0.74 | LMNA (0.67) | KDM4ECYP1A2CYP2D6ALOX15TDP1 | |
| SCHEMBL30477973 | 0.73 | KDM4E (0.48) | KDM4EMEN1KMT2AHTR2CMAPT | |
| Calcium SCHEMBL29917796 | 0.73 | LMNA (0.65) | KDM4ECYP1A2CYP2D6ALOX15TDP1 | |
| SCHEMBL28172745 | 0.73 | KDM4E (0.48) | KDM4EMEN1KMT2AHTR2CMAPT | |
| SCHEMBL2553660 | 0.71 | PARP1 (0.69) | KDM4ECYP1A2CYP2D6ALOX15TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041784-A1 | METHODS FOR DIAGNOSING AND TREATING CANCER | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2011-04-07 | — | — | WO | disclosed |
| EP-1824498-A2 | METHODS AND COMPOSITIONS FOR TREATING CELLULAR PROLIFERATIVE DISEASES | THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006053315-A2 | METHODS AND COMPOSITIONS FOR TREATING CELLULAR PROLIFERATIVE DISEASES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2006-05-18 | — | — | WO | disclosed |