Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | RB1 | P06400 | 1/20 | 0.44 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.44 |
| ▸ | HTR5A | P47898 | 4/20 | 0.44 |
| ▸ | GPR3 | P46089 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6529682 | 1.00 | HTR2A (0.53) | HTR2AHTR2CCYP1A2CYP2D6KDM4E | |
| SCHEMBL16559077 | 1.00 | HTR2A (0.53) | HTR2AHTR2CCYP1A2CYP2D6KDM4E | |
| SCHEMBL8791910 | 0.81 | HTR2A (0.56) | HTR2AHTR2CCYP1A2CYP2D6KDM4E | |
| SCHEMBL7406719 | 0.81 | HTR2A (0.53) | HTR2AHTR2CCYP1A2CYP2D6KDM4E | |
| SCHEMBL7412311 | 0.80 | HTR6 (0.61) | HTR2AHTR2CCYP1A2CYP2D6KDM4E | |
| SCHEMBL13877232 | 0.79 | HTR2A (0.50) | HTR2AHTR2CCYP1A2CYP2D6KDM4E | |
| SCHEMBL21088785 | 0.79 | RB1 (0.51) | HTR2AHTR2CCYP1A2CYP2D6KDM4E | |
| SCHEMBL18070796 | 0.79 | HTR2A (0.50) | HTR2AHTR2CCYP1A2CYP2D6KDM4E | |
| SCHEMBL10743921 | 0.78 | HTR2A (0.49) | HTR2AHTR2CCYP1A2CYP2D6KDM4E | |
| SCHEMBL6687023 | 0.77 | HTR6 (0.64) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170283781-A1 | BIOCATALYSTS AND METHODS FOR SYNTHESIZING DERIVATIVES OF TRYPTAMINE AND TRYPTAMINE ANALOGS | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2017-10-05 | — | — | US | disclosed |
| US-9708588-B2 | Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs | CODEXIS, INC. (US) | 2017-07-18 | — | — | US | disclosed |
| US-20160289649-A1 | BIOCATALYSTS AND METHODS FOR SYNTHESIZING DERIVATIVES OF TRYPTAMINE AND TRYPTAMINE ANALOGS | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2016-10-06 | — | — | US | disclosed |
| US-9388395-B2 | Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs | CODEXIS, INC. (US) | 2016-07-12 | — | — | US | disclosed |
| US-20150344854-A1 | BIOCATALYSTS AND METHODS FOR SYNTHESIZING DERIVATIVES OF TRYPTAMINE AND TRYPTAMINE ANALOGS | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2015-12-03 | — | — | US | disclosed |
| US-9139821-B2 | Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs | CODEXIS, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-20150072383-A1 | BIOCATALYSTS AND METHODS FOR SYNTHESIZING DERIVATIVES OF TRYPTAMINE AND TRYPTAMINE ANALOGS | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2015-03-12 | — | — | US | disclosed |