Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.48 |
| ▸ | CARM1 | Q86X55 | 4/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 5/20 | 0.41 |
| ▸ | HRH1 | P35367 | 4/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ACP3 | P15309 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16559386 | 0.88 | SLC6A2 (0.40) | SLC6A2CARM1HTR2ASLC6A4HTR2C | |
| SCHEMBL16559388 | 0.85 | SLC6A2 (0.39) | SLC6A2CARM1PDPK1HTR2AHRH1 | |
| Hydrochloric Acid SCHEMBL17968250 | 0.83 | HTR2A (0.38) | SLC6A2PDPK1HTR2AHRH1RET | |
| Hydrochloric Acid SCHEMBL16552476 | 0.83 | CYP2D6 (0.41) | HTR2AHRH1RETCHRM1DRD2 | |
| SCHEMBL6883953 | 0.81 | HTR2A (0.44) | PDPK1HTR2AHRH1RETCHRM1 | |
| SCHEMBL3394128 | 0.78 | CARM1 (0.46) | SLC6A2CARM1PDPK1HRH1 | |
| SCHEMBL16571162 | 0.78 | SLC6A2 (0.42) | SLC6A2CARM1HTR2ASLC6A4CHRM1 | |
| SCHEMBL16559364 | 0.78 | HTR2A (0.40) | SLC6A2CARM1HTR2ASLC6A4CHRM1 | |
| SCHEMBL16559367 | 0.78 | SLC6A2 (0.40) | SLC6A2CARM1HTR2AHRH1SLC6A4 | |
| Hydrochloric Acid SCHEMBL17968249 | 0.77 | HTR2A (0.46) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210186969-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | Janssen Biopharma, Inc. (US) | 2021-06-24 | — | — | US | disclosed |
| US-10980805-B2 | Aza-pyridone compounds and uses thereof | Janssen Biopharma, Inc. (US) | 2021-04-20 | — | — | US | disclosed |
| EP-3030566-B1 | 7,8-DIHYDRO-3H-PYRAZINO[1,2-B]PYRIDAZINE-3,5(6H)-DIONE COMPOUNDS AND USES THEREOF | JANSSEN BIOPHARMA INC (US) | 2020-07-08 | — | — | EP | disclosed |
| US-10702523-B2 | AZA-pyridone compounds and uses thereof | Janssen Biopharma, Inc. (US) | 2020-07-07 | — | — | US | disclosed |
| US-20200030328-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | Janssen Biopharma, Inc. (US) | 2020-01-30 | — | — | US | disclosed |
| US-20190314373-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | ALIOS BIOPHARMA, INC. (US) | 2019-10-17 | — | — | US | disclosed |
| US-10251882-B2 | Aza-pyridone compounds and uses thereof | ALIOS BIOPHARMA, INC. (US) | 2019-04-09 | — | — | US | disclosed |
| US-20160228438-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | ALIOS BIOPHARMA, INC. | 2016-08-11 | — | — | US | disclosed |
| US-20160228438-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | ALIOS BIOPHARMA, INC. | 2016-08-11 | — | — | US | disclosed |
| US-9328119-B2 | AZA-pyridone compounds and uses thereof | ALIOS BIOPHARMA, INC. (US) | 2016-05-03 | — | — | US | disclosed |
| US-9328119-B2 | AZA-pyridone compounds and uses thereof | ALIOS BIOPHARMA, INC. (US) | 2016-05-03 | — | — | US | disclosed |
| US-20150072982-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | Janssen Pharmaceuticals, Inc. | 2015-03-12 | — | — | US | disclosed |
| US-20150072982-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | Janssen Pharmaceuticals, Inc. | 2015-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200030328-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | PNPO, ITPA, PDXK | SLC6A2 3848/4885CARM1 1699/4885PDPK1 893/4885 |
| US-10980805-B2 | Aza-pyridone compounds and uses thereof | PNPO, ITPA, PDXK | SLC6A2 3848/4885CARM1 1699/4885PDPK1 893/4885 |
| US-20190314373-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | PNPO, ITPA, PDXK | SLC6A2 3848/4885CARM1 1699/4885PDPK1 893/4885 |
| US-10251882-B2 | Aza-pyridone compounds and uses thereof | PNPO, ITPA, PDXK | SLC6A2 3848/4885CARM1 1699/4885PDPK1 893/4885 |
| US-20210186969-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | PNPO, ITPA, PDXK | SLC6A2 3848/4885CARM1 1699/4885PDPK1 893/4885 |
| US-10702523-B2 | AZA-pyridone compounds and uses thereof | PNPO, ITPA, PDXK | SLC6A2 3848/4885CARM1 1699/4885PDPK1 893/4885 |
| US-20160228438-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | PNPO, ITPA, PDXK | SLC6A2 3848/4885CARM1 1699/4885PDPK1 893/4885 |
| US-20150072982-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | PNPO, ITPA, PDXK | SLC6A2 3848/4885CARM1 1699/4885PDPK1 893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.