Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | ACP3 | P15309 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | PRCP | P42785 | 3/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16559341 | 0.81 | SLC6A2 (0.48) | HTR2ARETACP3DRD2CHRM1 | |
| Hydrochloric Acid SCHEMBL17968250 | 0.80 | HTR2A (0.38) | HTR2ARETACP3DRD2CHRM1 | |
| SCHEMBL11364491 | 0.79 | HTR1A (0.43) | DRD2ADRA2BADRA2CADRA1APRCP | |
| SCHEMBL10754709 | 0.79 | HTR2A (0.50) | HTR2ARETACP3DRD2CHRM1 | |
| SCHEMBL10443710 | 0.78 | TACR1 (0.54) | HTR2ARETACP3DRD2CHRM1 | |
| Hydrochloric Acid SCHEMBL16552476 | 0.77 | CYP2D6 (0.41) | HTR2ARETDRD2CHRM1ADRA2B | |
| SCHEMBL20345842 | 0.75 | HTR2A (0.40) | HTR2ARETACP3DRD2CHRM1 | |
| SCHEMBL23605201 | 0.74 | PRCP (0.55) | HTR2ARETACP3DRD2CHRM1 | |
| SCHEMBL13801969 | 0.72 | ACP3 (0.43) | HTR2ARETACP3PRCP | |
| Hydrochloric Acid SCHEMBL17968249 | 0.72 | HTR2A (0.46) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037892-B1 | PIPERIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2004-10-06 | — | — | EP | disclosed |
| US-6166209-A | Piperidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2000-12-26 | — | — | US | disclosed |