Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UPP1 | Q16831 | 4/20 | 1.00 |
| ▸ | TYMP | P19971 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PNP | P00491 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PDE9A | O76083 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16561913 | 0.82 | UPP1 (1.00) | UPP1TYMPKDM4EATMALDH1A1 | |
| SCHEMBL16561915 | 0.80 | UPP1 (1.00) | UPP1TYMPKDM4EATMALDH1A1 | |
| SCHEMBL6655303 | 0.76 | UPP1 (0.68) | UPP1KDM4EATMALDH1A1CYP2C9 | |
| SCHEMBL9114390 | 0.75 | UPP1 (0.80) | UPP1TYMPKDM4EATMALDH1A1 | |
| SCHEMBL16561918 | 0.71 | UPP1 (1.00) | UPP1KDM4EATMALDH1A1CYP2C9 | |
| SCHEMBL8025123 | 0.71 | UPP1 (0.64) | UPP1KDM4EATMALDH1A1CYP2C9 | |
| SCHEMBL5182348 | 0.71 | UPP1 (0.64) | UPP1KDM4EATMALDH1A1CYP2C9 | |
| SCHEMBL16561956 | 0.69 | UPP1 (0.74) | UPP1KDM4EATMALDH1A1CYP2C9 | |
| SCHEMBL8941878 | 0.69 | UPP1 (0.61) | UPP1TYMPKDM4EATMALDH1A1 | |
| SCHEMBL8901518 | 0.69 | UPP1 (0.61) | UPP1KDM4EATMALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9700547-B2 | Use of 6-hydroxy-2-pyridones and derivatives thereof for preparing a pharmaceutical composition that acts by inhibiting the human uridine phosphorylase enzyme | UNIÃO BRASILEIRA DE EDUCAÇÃO E ASSISTÊNCIA, MANTENEDORA DA PUCRS (BR) | 2017-07-11 | — | — | US | disclosed |
| EP-3042657-A1 | USE OF 6-HYDROXY-2-PYRIDONES AND DERIVATIVES THEREOF FOR PREPARING A PHARMACEUTICAL COMPOSITION THAT ACTS BY INHIBITING THE HUMAN URIDINE PHOSPHORYLASE ENZYME | UNIÃO BRASILEIRA DE EDUCAÇAO E ASSISTÊNCIA- MANTENEDORA DA PUCRS (BR) | 2016-07-13 | — | — | EP | disclosed |
| US-20160193197-A1 | USE OF 6-HYDROXY-2-PYRIDONES AND DERIVATIVES THEREOF FOR PREPARING A PHARMACEUTICAL COMPOSITION THAT ACTS BY INHIBITING THE HUMAN URIDINE PHOSPHORYLASE ENZYME | UNIÃO BRASILEIRA DE EDUCAÇÃO E ASSISTÊNCIA, MANTENEDORA DA PUCRS (BR) | 2016-07-07 | — | — | US | disclosed |
| WO-2015031968-A1 | USE OF 6-HYDROXY-2-PYRIDONES AND DERIVATIVES THEREOF FOR PREPARING A PHARMACEUTICAL COMPOSITION THAT ACTS BY INHIBITING THE HUMAN URIDINE PHOSPHORYLASE ENZYME | UNIÃO BRASILEIRA DE EDUCAÇÃO E ASSISTÊNCIA, MANTENEDORA DA PUCRS (BR) | 2015-03-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160193197-A1 | USE OF 6-HYDROXY-2-PYRIDONES AND DERIVATIVES THEREOF FOR PREPARING A PHARMACEUTICAL COMPOSITION THAT ACTS BY INHIBITING THE HUMAN URIDINE PHOSPHORYLASE ENZYME | UPP1, PNP, TYMP | UPP1 1/4885TYMP 3/4885KDM4E 1417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.