Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 10/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17066875 | 0.89 | AURKB (0.41) | NAMPTMAPKAPK2HDAC8 | |
| SCHEMBL29391711 | 0.87 | CA1 (0.44) | HDAC8MAPK14 | |
| SCHEMBL30921556 | 0.85 | CA1 (0.53) | HDAC8 | |
| SCHEMBL25381461 | 0.81 | CYP17A1 (0.52) | NAMPTMAPKAPK2CYP17A1HDAC8MAPK14 | |
| SCHEMBL17247383 | 0.80 | MAPKAPK2 (0.53) | NAMPTMAPKAPK2CYP17A1MAPK14PSMB8 | |
| SCHEMBL853159 | 0.80 | NAMPT (0.49) | NAMPTMAPKAPK2CYP17A1MAPK14PSMB8 | |
| SCHEMBL29850092 | 0.80 | NAMPT (0.49) | NAMPTMAPKAPK2CYP17A1MAPK14PSMB8 | |
| SCHEMBL17060912 | 0.80 | P4HTM (0.37) | HDAC8 | |
| SCHEMBL17060910 | 0.80 | P4HTM (0.37) | HDAC8 | |
| SCHEMBL925018 | 0.79 | NAMPT (0.48) | NAMPTMAPKAPK2CYP17A1PSMB8MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11067580-B2 | Compounds and methods for conjugation of biomolecules | Life Technologies Corporation (US) | 2021-07-20 | — | — | US | disclosed |
| US-20200333351-A1 | Compounds and Methods for Conjugation of Biomolecules | Life Technologies Corporation | 2020-10-22 | — | — | US | disclosed |
| US-10648985-B2 | Compounds and methods for conjugation of biomolecules | Life Technologies Corporation (US) | 2020-05-12 | — | — | US | disclosed |
| US-20190079095-A1 | COMPOUNDS AND METHODS FOR CONJUGATION OF BIOMOLECULES | Life Technologies Corporation | 2019-03-14 | — | — | US | disclosed |
| EP-2966061-B1 | COMPOUNDS AND METHODS FOR CONJUGATION OF BIOMOLECULES | LIFE TECHNOLOGIES CORP (US) | 2017-05-03 | — | — | EP | disclosed |
| CN-103502218-B | Compounds and methods for for conjugating biomolecules | 生命科技公司 | 2016-08-17 | — | — | CN | disclosed |
| EP-2966061-A1 | COMPOUNDS AND METHODS FOR CONJUGATION OF BIOMOLECULES | Life Technologies Corporation (US) | 2016-01-13 | — | — | EP | disclosed |
| EP-2681196-B1 | COMPOUNDS AND METHODS FOR CONJUGATION OF BIOMOLECULES | LIFE TECHNOLOGIES CORP (US) | 2015-09-09 | — | — | EP | disclosed |
| US-20150072396-A1 | Compounds and Methods for Conjugation of Biomolecules | Life Technologies Corporation (US) | 2015-03-12 | — | — | US | disclosed |
| CN-103502218-A | Compounds and methods for conjugation of biomolecules | LIFE TECHNOLOGIES CORP | 2014-01-08 | — | — | CN | disclosed |
| WO-2012121973-A1 | COMPOUNDS AND METHODS FOR CONJUGATION OF BIOMOLECULES | Life Technologies Corporation (US) | 2012-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190079095-A1 | COMPOUNDS AND METHODS FOR CONJUGATION OF BIOMOLECULES | LIG3, LIG1, HLCS | NAMPT 2829/4885MAPKAPK2 3506/4885CYP17A1 1722/4885 |
| US-20200333351-A1 | Compounds and Methods for Conjugation of Biomolecules | LIG3, LIG1, HLCS | NAMPT 2829/4885MAPKAPK2 3506/4885CYP17A1 1722/4885 |
| US-11067580-B2 | Compounds and methods for conjugation of biomolecules | LIG3, LIG1, HLCS | NAMPT 2829/4885MAPKAPK2 3506/4885CYP17A1 1722/4885 |
| US-10648985-B2 | Compounds and methods for conjugation of biomolecules | LIG3, LIG1, HLCS | NAMPT 2829/4885MAPKAPK2 3506/4885CYP17A1 1722/4885 |
| US-20150072396-A1 | Compounds and Methods for Conjugation of Biomolecules | LIG3, LIG1, HLCS | NAMPT 2829/4885MAPKAPK2 3506/4885CYP17A1 1722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.