Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29391711 | 0.90 | CA1 (0.44) | HDAC8CA1CA2MAPTKDM4E | |
| SCHEMBL16562887 | 0.89 | NAMPT (0.43) | HDAC8NAMPTMAPKAPK2 | |
| SCHEMBL30921556 | 0.88 | CA1 (0.53) | HDAC8HDAC3HDAC1HDAC10HDAC6 | |
| SCHEMBL23651894 | 0.82 | AURKB (0.45) | AURKBEGFRRAF1KDRMAP2K2 | |
| SCHEMBL18653616 | 0.78 | AURKB (0.47) | AURKBEGFRRAF1KDRMAP2K2 | |
| SCHEMBL15299581 | 0.77 | GABRA5 (0.45) | EGFRCA1CA2MAPTKDM4E | |
| SCHEMBL25733684 | 0.76 | AURKB (0.46) | AURKBEGFRRAF1KDRMAP2K2 | |
| SCHEMBL8693590 | 0.76 | CA1 (0.54) | AURKBEGFRRAF1KDRMAP2K2 | |
| SCHEMBL17060912 | 0.75 | P4HTM (0.37) | HDAC8HDAC3HDAC1HDAC6MAPT | |
| SCHEMBL17060910 | 0.75 | P4HTM (0.37) | HDAC8HDAC3HDAC1HDAC6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11067580-B2 | Compounds and methods for conjugation of biomolecules | Life Technologies Corporation (US) | 2021-07-20 | — | — | US | disclosed |
| US-20200333351-A1 | Compounds and Methods for Conjugation of Biomolecules | Life Technologies Corporation | 2020-10-22 | — | — | US | disclosed |
| US-10648985-B2 | Compounds and methods for conjugation of biomolecules | Life Technologies Corporation (US) | 2020-05-12 | — | — | US | disclosed |
| US-20190079095-A1 | COMPOUNDS AND METHODS FOR CONJUGATION OF BIOMOLECULES | Life Technologies Corporation | 2019-03-14 | — | — | US | disclosed |
| EP-2966061-A1 | COMPOUNDS AND METHODS FOR CONJUGATION OF BIOMOLECULES | Life Technologies Corporation (US) | 2016-01-13 | — | — | EP | disclosed |
| EP-2681196-B1 | COMPOUNDS AND METHODS FOR CONJUGATION OF BIOMOLECULES | LIFE TECHNOLOGIES CORP (US) | 2015-09-09 | — | — | EP | disclosed |
| WO-2012121973-A1 | COMPOUNDS AND METHODS FOR CONJUGATION OF BIOMOLECULES | Life Technologies Corporation (US) | 2012-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190079095-A1 | COMPOUNDS AND METHODS FOR CONJUGATION OF BIOMOLECULES | LIG3, LIG1, HLCS | AURKB 813/4885EGFR 2115/4885RAF1 4122/4885 |
| US-20200333351-A1 | Compounds and Methods for Conjugation of Biomolecules | LIG3, LIG1, HLCS | AURKB 813/4885EGFR 2115/4885RAF1 4122/4885 |
| US-11067580-B2 | Compounds and methods for conjugation of biomolecules | LIG3, LIG1, HLCS | AURKB 813/4885EGFR 2115/4885RAF1 4122/4885 |
| US-10648985-B2 | Compounds and methods for conjugation of biomolecules | LIG3, LIG1, HLCS | AURKB 813/4885EGFR 2115/4885RAF1 4122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.