Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 17/20 | 0.63 |
| ▸ | GSK3A | P49840 | 3/20 | 0.63 |
| ▸ | GSK3B | P49841 | 2/20 | 0.63 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.63 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.63 |
| ▸ | AURKA | O14965 | 1/20 | 0.63 |
| ▸ | ABL1 | P00519 | 1/20 | 0.63 |
| ▸ | LCK | P06239 | 1/20 | 0.63 |
| ▸ | MET | P08581 | 1/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.63 |
| ▸ | FLT1 | P17948 | 1/20 | 0.63 |
| ▸ | KDR | P35968 | 1/20 | 0.63 |
| ▸ | FLT3 | P36888 | 1/20 | 0.63 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.63 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.63 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.63 |
| ▸ | MST1R | Q04912 | 1/20 | 0.63 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.63 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16564577 | 0.90 | CDK9 (0.77) | CDK9GSK3AGSK3BCDK5MAP4K4 | |
| Hydrochloric Acid SCHEMBL17257732 | 0.84 | CDK9 (0.77) | CDK9GSK3AGSK3BCDK5MAP4K4 | |
| SCHEMBL3004001 | 0.83 | CDK9 (0.75) | CDK9GSK3AGSK3BCDK5MAP4K4 | |
| SCHEMBL12487249 | 0.81 | CDK9 (0.57) | CDK9GSK3AGSK3BCDK5MAP4K4 | |
| SCHEMBL8516163 | 0.81 | CDK9 (0.81) | CDK9GSK3ACDK5MAP4K4LRRK2 | |
| SCHEMBL16564576 | 0.81 | CDK9 (0.61) | CDK9GSK3AGSK3BCDK5MAP4K4 | |
| SCHEMBL14874685 | 0.80 | CDK9 (0.68) | CDK9GSK3AGSK3BCDK5MAP4K4 | |
| Trifluoroacetic Acid SCHEMBL17257723 | 0.79 | CDK9 (0.68) | CDK9GSK3AGSK3BCDK5MAP4K4 | |
| SCHEMBL14161111 | 0.77 | CDK9 (1.00) | CDK9GSK3AGSK3BCDK5MAP4K4 | |
| SCHEMBL15720507 | 0.75 | CDK9 (0.72) | CDK9GSK3AGSK3BCDK5CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137163-B1 | INHIBITORS OF PROTEIN KINASES | ASTRAZENECA AB (SE) | 2015-03-18 | — | — | EP | claimed |