Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 12/20 | 0.60 |
| ▸ | AR | P10275 | 10/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | SHBG | P04278 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3763965 | 0.88 | PGR (0.60) | PGRARLMNACYP3A4ABCB11 | |
| SCHEMBL16564563 | 0.88 | PGR (0.49) | PGRARLMNACYP3A4ABCB11 | |
| SCHEMBL16564393 | 0.86 | PGR (0.58) | PGRARLMNACYP3A4ABCB11 | |
| SCHEMBL13372581 | 0.82 | PGR (0.60) | PGRARLMNACYP3A4ABCB11 | |
| SCHEMBL13372652 | 0.82 | PGR (0.60) | PGRARLMNACYP3A4ABCB11 | |
| SCHEMBL16564466 | 0.82 | PGR (0.41) | PGRARLMNACYP3A4CYP2C19 | |
| SCHEMBL16564562 | 0.82 | PGR (0.63) | PGRARLMNACYP3A4CYP2C19 | |
| SCHEMBL16564430 | 0.82 | PGR (0.63) | PGRARLMNACYP3A4CYP2C19 | |
| SCHEMBL924095 | 0.79 | PGR (0.60) | PGRARLMNACYP3A4ABCB11 | |
| SCHEMBL921539 | 0.79 | PGR (0.60) | PGRARLMNACYP3A4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238149-B1 | 19-NOR-STEROID DERIVATIVES WITH A 15ALPHA, 16ALPHA-METHYLENE GROUP AND A SATURATED 17,17-SPIROLACTONE RING, USE THEREOF, AND MEDICAMENTS CONTAINING SAID DERIVATIVES | BAYER IP GMBH (DE) | 2015-03-18 | — | — | EP | disclosed |