Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 20/20 | 0.59 |
| ▸ | DLK1 | P80370 | 1/20 | 0.54 |
| ▸ | DRG1 | Q9Y295 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15602409 | 1.00 | MAP3K12 (0.59) | MAP3K12DLK1DRG1 | |
| SCHEMBL15602526 | 0.90 | MAP3K12 (0.68) | MAP3K12DLK1DRG1 | |
| SCHEMBL19910124 | 0.90 | MAP3K12 (0.68) | MAP3K12DLK1DRG1 | |
| SCHEMBL15602434 | 0.89 | MAP3K12 (0.75) | MAP3K12 | |
| SCHEMBL19910123 | 0.89 | MAP3K12 (0.56) | MAP3K12DLK1DRG1 | |
| SCHEMBL16568100 | 0.89 | MAP3K12 (0.75) | MAP3K12 | |
| SCHEMBL16220464 | 0.87 | MAP3K12 (0.77) | MAP3K12 | |
| SCHEMBL22227604 | 0.87 | MAP3K12 (0.77) | MAP3K12 | |
| SCHEMBL19910126 | 0.81 | MAP3K12 (0.56) | MAP3K12DLK1DRG1 | |
| SCHEMBL19910217 | 0.81 | MAP3K12 (0.53) | MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2852584-B1 | SUBSTITUTED DIPYRIDYLAMINES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |
| US-9399636-B2 | Substituted dipyridylamines and uses thereof | GENENTECH, INC. (US) | 2016-07-26 | — | — | US | disclosed |
| US-20150080367-A1 | SUBSTITUTED DIPYRIDYLAMINES AND USES THEREOF | GENENTECH, INC. (US) | 2015-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150080367-A1 | SUBSTITUTED DIPYRIDYLAMINES AND USES THEREOF | PDXK, PRMT1, DMPK | MAP3K12 367/4885DLK1 24/4885DRG1 609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.