Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1660197 | 0.91 | ALDH1A1 (0.47) | ALDH1A1NPSR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1658364 | 0.90 | MEN1 (0.45) | ALDH1A1NPSR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1658109 | 0.90 | ALDH1A1 (0.55) | ALDH1A1NPSR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1657196 | 0.81 | ALDH1A1 (0.54) | ALDH1A1NPSR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL10149773 | 0.80 | ROCK1 (0.52) | ALDH1A1NPSR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1657527 | 0.80 | ALDH1A1 (0.59) | ALDH1A1NPSR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1660083 | 0.80 | ROCK1 (0.46) | ALDH1A1NPSR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1659768 | 0.80 | ALDH1A1 (0.49) | ALDH1A1NPSR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1658238 | 0.79 | KDM4E (0.58) | ALDH1A1NPSR1TSHRROCK1HSD17B10 | |
| SCHEMBL1658324 | 0.79 | ROCK2 (0.56) | ALDH1A1NPSR1CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2214667-A2 | SMALL MOLECULE INHIBITORS OF PARP ACTIVITY | Angion Biomedica Corp. (US) | 2010-08-11 | — | — | EP | claimed |
| WO-2009054952-A2 | SMALL MOLECULE INHIBITORS OF PARP ACTIVITY | ANGION BIOMEDICA CORP. (US) | 2009-04-30 | — | — | WO | claimed |
| US-20110098304-A1 | Small molecule inhibitors of PARP activity | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-04-28 | — | — | US | disclosed |
| EP-2214667-A2 | SMALL MOLECULE INHIBITORS OF PARP ACTIVITY | Angion Biomedica Corp. (US) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009054952-A2 | SMALL MOLECULE INHIBITORS OF PARP ACTIVITY | ANGION BIOMEDICA CORP. (US) | 2009-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098304-A1 | Small molecule inhibitors of PARP activity | PARP1, PARP11, PARP2 | ALDH1A1 1621/4885NPSR1 4134/4885CYP1A2 4338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.