Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 3/20 | 0.40 |
| ▸ | CHUK | O15111 | 3/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.39 |
| ▸ | XDH | P47989 | 4/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 2/20 | 0.33 |
| ▸ | CDK8 | P49336 | 2/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | MAP2 | P11137 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16571180 | 0.90 | SLC22A12 (0.42) | SLC22A12XDHPARP1GRM2CCNC | |
| SCHEMBL19478363 | 0.88 | SCN9A (0.41) | IKBKBCHUKSLC22A12XDHPARP1 | |
| SCHEMBL16571716 | 0.86 | MAP2 (0.43) | IKBKBCHUKSLC22A12XDHPARP1 | |
| SCHEMBL16571739 | 0.86 | XDH (0.40) | SLC22A12XDHPARP1KDM1AGRM2 | |
| SCHEMBL19478158 | 0.86 | GRM2 (0.45) | SLC22A12XDHKDM1AGRM2CCNC | |
| SCHEMBL16571634 | 0.86 | SLC22A12 (0.38) | SLC22A12XDHKDM1ARXRARXRG | |
| SCHEMBL19478348 | 0.86 | IKBKB (0.39) | IKBKBCHUKPARP1DGAT1CCNC | |
| SCHEMBL16571636 | 0.84 | IKBKB (0.34) | IKBKBCHUKPARP1KDM1A | |
| SCHEMBL19478334 | 0.84 | XDH (0.38) | IKBKBCHUKSLC22A12XDHPARP1 | |
| SCHEMBL16571181 | 0.84 | CCNC (0.51) | SLC22A12XDHCCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044207-B1 | INDOL-CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-10-18 | — | — | EP | claimed |
| EP-3044207-B1 | INDOL-CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-10-18 | — | — | EP | disclosed |
| EP-3044207-A1 | INDOL-CARBOXAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-07-20 | — | — | EP | disclosed |
| WO-2015036412-A1 | INDOL-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-03-19 | — | — | WO | disclosed |
| WO-2015036412-A1 | INDOL-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-03-19 | — | — | WO | disclosed |