Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.38 |
| ▸ | XDH | P47989 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NHERF1 | O14745 | 2/20 | 0.37 |
| ▸ | PYGL | P06737 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 3/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19478398 | 0.88 | XDH (0.39) | SLC22A12XDHALOX15PTPN11EGLN1 | |
| SCHEMBL16571420 | 0.87 | ALOX15 (0.49) | SLC22A12XDHALOX15PTPN11SYK | |
| SCHEMBL16571417 | 0.87 | XDH (0.38) | SLC22A12XDHALOX15PTPN11EGLN1 | |
| SCHEMBL16571408 | 0.86 | IKBKB (0.40) | SLC22A12XDHKDM1ARXRARXRG | |
| SCHEMBL16571038 | 0.85 | MAPK14 (0.42) | — | |
| SCHEMBL16571097 | 0.85 | CCNC (0.46) | SLC22A12XDHALOX15PTPN11SYK | |
| SCHEMBL16571094 | 0.84 | PTGDR2 (0.41) | SLC22A12XDHALOX15RXRARXRG | |
| SCHEMBL16571371 | 0.83 | KDR (0.39) | SLC22A12XDHALOX15MMP2 | |
| SCHEMBL16571121 | 0.83 | XDH (0.39) | SLC22A12XDHALOX15PTPN11KDM1A | |
| SCHEMBL16571276 | 0.81 | KDM4E (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044207-A1 | INDOL-CARBOXAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-07-20 | — | — | EP | disclosed |
| WO-2015036412-A1 | INDOL-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-03-19 | — | — | WO | disclosed |