SCHEMBL16573283

SCHEMBL16573283

COC(=O)Nc1cc([N+](=O)[O-])cc(C)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl

nearest known ligand 0.59

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 3/20 0.40
HTT P42858 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
RORC P51449 2/20 0.35
PKM P14618 1/20 0.34
MAPT P10636 3/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
LMNA P02545 1/20 0.33
PDE4A P27815 1/20 0.33
PDE4B Q07343 1/20 0.33
PDE4C Q08493 1/20 0.33
PDE4D Q08499 1/20 0.33
MALT1 Q9UDY8 1/20 0.33
POLB P06746 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16564146 0.93 DHODH (0.42) DHODHHTTSMN1; SMN2NPC1RAB9A
SCHEMBL16564143 0.93 DHODH (0.42) DHODHHTTSMN1; SMN2NPC1RAB9A
SCHEMBL12559235 0.88 DHODH (0.39) DHODHHTTSMN1; SMN2NPC1RAB9A
SCHEMBL16573264 0.86 DHODH (0.49) DHODHSMN1; SMN2NPC1RAB9AMAPT
SCHEMBL29114109 0.85 DHODH (0.41) DHODHHTTSMN1; SMN2NPC1RAB9A
SCHEMBL18060398 0.83 DHODH (0.39) DHODHHTTSMN1; SMN2NPC1RAB9A
SCHEMBL12911766 0.83 DHODH (0.40) DHODHHTTSMN1; SMN2NPC1RAB9A
SCHEMBL13072537 0.83 DHODH (0.38) DHODHHTTSMN1; SMN2NPC1RAB9A
SCHEMBL950072 0.82 DHODH (0.39) DHODHHTTSMN1; SMN2NPC1RAB9A
SCHEMBL12528017 0.81 DHODH (0.39) DHODHHTTSMN1; SMN2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2848613-B1 DIAMINOARYL DERIVATIVES SUBSTITUTED BY CARBAMATE AND PESTICIDAL COMPOSITION CONTAINING SAME KYUNG NONG CORP (KR) 2016-09-21 EP disclosed
US-9018233-B2 Diaminoaryl derivatives substituted by carbamate and pesticidal composition containing same KYUNG NONG CORPORATION (KR) 2015-04-28 US disclosed
US-20150094342-A1 DIAMINOARYL DERIVATIVES SUBSTITUTED BY CARBAMATE AND PESTICIDAL COMPOSITION CONTAINING SAME KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2015-04-02 US disclosed
EP-2848613-A1 DIAMINOARYL DERIVATIVES SUBSTITUTED BY CARBAMATE AND PESTICIDAL COMPOSITION CONTAINING SAME Kyung Nong Corporation (KR) 2015-03-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150094342-A1 DIAMINOARYL DERIVATIVES SUBSTITUTED BY CARBAMATE AND PESTICIDAL COMPOSITION CONTAINING SAME DDT, DDC, DPP3 DHODH 224/4885HTT 3248/4885SMN1; SMN2 3099/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.