SCHEMBL16573264

SCHEMBL16573264

COC(=O)Nc1cccc(C)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl

nearest known ligand 0.63

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 3/20 0.49
JAK2 O60674 1/20 0.36
JAK1 P23458 1/20 0.36
TYK2 P29597 1/20 0.36
KMT2A Q03164 2/20 0.36
MALT1 Q9UDY8 2/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
MAPT P10636 2/20 0.35
TP53 P04637 1/20 0.35
LCK P06239 3/20 0.35
CHRNA7 P36544 2/20 0.35
RBP4 P02753 1/20 0.35
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
HPGD P15428 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
MAPK14 Q16539 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16564047 0.92 DHODH (0.51) DHODHKMT2AMALT1NPC1RAB9A
SCHEMBL13318558 0.87 DHODH (0.48) DHODHJAK2JAK1TYK2KMT2A
SCHEMBL16573283 0.86 DHODH (0.40) DHODHKMT2AMALT1NPC1RAB9A
SCHEMBL16563751 0.85 DHODH (0.48) DHODHMALT1MAPTLCKCHRNA7
SCHEMBL3086322 0.85 DHODH (0.49) DHODHMALT1MAPTLCKCHRNA7
SCHEMBL842004 0.83 DHODH (0.51) DHODHMALT1RAB9AMAPTLCK
SCHEMBL13072406 0.83 DHODH (0.41) DHODHJAK2JAK1TYK2KMT2A
SCHEMBL13072490 0.82 DHODH (0.46) DHODHJAK2JAK1TYK2KMT2A
SCHEMBL16564186 0.82 DHODH (0.46) DHODHKMT2AMALT1MAPTALDH1A1
SCHEMBL535832 0.82 KMT2A (0.41) DHODHKMT2AMALT1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2848613-B1 DIAMINOARYL DERIVATIVES SUBSTITUTED BY CARBAMATE AND PESTICIDAL COMPOSITION CONTAINING SAME KYUNG NONG CORP (KR) 2016-09-21 EP disclosed
US-9018233-B2 Diaminoaryl derivatives substituted by carbamate and pesticidal composition containing same KYUNG NONG CORPORATION (KR) 2015-04-28 US disclosed
US-20150094342-A1 DIAMINOARYL DERIVATIVES SUBSTITUTED BY CARBAMATE AND PESTICIDAL COMPOSITION CONTAINING SAME KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2015-04-02 US disclosed
EP-2848613-A1 DIAMINOARYL DERIVATIVES SUBSTITUTED BY CARBAMATE AND PESTICIDAL COMPOSITION CONTAINING SAME Kyung Nong Corporation (KR) 2015-03-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150094342-A1 DIAMINOARYL DERIVATIVES SUBSTITUTED BY CARBAMATE AND PESTICIDAL COMPOSITION CONTAINING SAME DDT, DDC, DPP3 DHODH 224/4885JAK2 2888/4885JAK1 3533/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.