Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 11/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 3/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.41 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1657138 | 0.93 | ROCK2 (0.58) | KDM4EALDH1A1POLBGAAMAPT | |
| SCHEMBL1658243 | 0.89 | KDM4E (0.51) | KDM4EALDH1A1POLBGAAMAPT | |
| SCHEMBL1657467 | 0.88 | ALDH1A1 (0.57) | KDM4EALDH1A1POLBGAAMAPT | |
| SCHEMBL1658238 | 0.84 | KDM4E (0.58) | KDM4EALDH1A1POLBGAAMAPT | |
| SCHEMBL1658801 | 0.84 | KDM4E (0.64) | KDM4EALDH1A1POLBGAAMAPT | |
| SCHEMBL1658362 | 0.83 | ALDH1A1 (0.52) | KDM4EALDH1A1POLBGAAMAPT | |
| SCHEMBL12909290 | 0.83 | POLB (0.65) | KDM4EALDH1A1POLBGAAMAPT | |
| SCHEMBL1658774 | 0.82 | ALDH1A1 (0.56) | KDM4EALDH1A1POLBGAAMAPT | |
| SCHEMBL1658864 | 0.82 | ALDH1A1 (0.61) | KDM4EALDH1A1POLBGAAMAPT | |
| SCHEMBL10149809 | 0.82 | POLB (0.64) | KDM4EALDH1A1POLBGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098304-A1 | Small molecule inhibitors of PARP activity | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-04-28 | — | — | US | claimed |
| US-20110098304-A1 | Small molecule inhibitors of PARP activity | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098304-A1 | Small molecule inhibitors of PARP activity | PARP1, PARP11, PARP2 | KDM4E 3283/4885ALDH1A1 1621/4885POLB 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.