Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.65 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.65 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.65 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.65 |
| ▸ | ABL1 | P00519 | 14/20 | 0.63 |
| ▸ | SRC | P12931 | 2/20 | 0.63 |
| ▸ | BCR | P11274 | 10/20 | 0.58 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.57 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.57 |
| ▸ | KIT | P10721 | 2/20 | 0.56 |
| ▸ | LDLR | P01130 | 1/20 | 0.56 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.54 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.54 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16581574 | 1.00 | MAPK14 (0.65) | MAPK14MAP3K20MAP3K7MAP4K2ABL1 | |
| SCHEMBL16581560 | 0.90 | MAPK14 (0.76) | MAPK14MAP3K20MAP3K7MAP4K2ABL1 | |
| SCHEMBL16581559 | 0.90 | MAPK14 (0.76) | MAPK14MAP3K20MAP3K7MAP4K2ABL1 | |
| SCHEMBL16581618 | 0.83 | CSK (0.63) | MAPK14MAP3K20MAP3K7MAP4K2ABL1 | |
| SCHEMBL16581617 | 0.83 | CSK (0.63) | MAPK14MAP3K20MAP3K7MAP4K2ABL1 | |
| SCHEMBL24071010 | 0.82 | NR2E1 (0.71) | MAP3K7MAP4K2ABL1SRCBCR | |
| SCHEMBL30211941 | 0.82 | NR2E1 (0.71) | MAP3K7MAP4K2ABL1SRCBCR | |
| SCHEMBL13659898 | 0.81 | NR2E1 (0.77) | MAP3K7MAP4K2ABL1SRCBCR | |
| SCHEMBL17325096 | 0.81 | ABL1 (0.62) | MAPK14MAP3K20ABL1SRCBCR | |
| SCHEMBL3424818 | 0.80 | MAPK14 (0.62) | MAPK14MAP3K20MAP3K7MAP4K2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519517-B1 | TYPE II RAF KINASE INHIBITORS | DANA FARBER CANCER INST INC (US) | 2015-03-25 | — | — | EP | claimed |
| US-9180127-B2 | Type II Raf kinase inhibitors | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-11-10 | — | — | US | disclosed |