Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.76 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.76 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.65 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.65 |
| ▸ | ABL1 | P00519 | 11/20 | 0.62 |
| ▸ | SRC | P12931 | 3/20 | 0.62 |
| ▸ | CSK | P41240 | 3/20 | 0.60 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.58 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | RAF1 | P04049 | 1/20 | 0.58 |
| ▸ | LYN | P07948 | 1/20 | 0.58 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.58 |
| ▸ | ABL2 | P42684 | 1/20 | 0.58 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.58 |
| ▸ | LDLR | P01130 | 1/20 | 0.57 |
| ▸ | KIT | P10721 | 1/20 | 0.57 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.57 |
| ▸ | BCR | P11274 | 7/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16581559 | 1.00 | MAPK14 (0.76) | MAPK14MAP3K20MAP3K7MAP4K2ABL1 | |
| SCHEMBL16581574 | 0.90 | MAPK14 (0.65) | MAPK14MAP3K20MAP3K7MAP4K2ABL1 | |
| SCHEMBL16581572 | 0.90 | MAPK14 (0.65) | MAPK14MAP3K20MAP3K7MAP4K2ABL1 | |
| SCHEMBL17208618 | 0.81 | MAPK14 (0.76) | MAPK14MAP3K20MAP3K7MAP4K2ABL1 | |
| SCHEMBL24071010 | 0.81 | NR2E1 (0.71) | MAP3K7MAP4K2ABL1SRCNR2E1 | |
| SCHEMBL30211941 | 0.81 | NR2E1 (0.71) | MAP3K7MAP4K2ABL1SRCNR2E1 | |
| SCHEMBL13659898 | 0.80 | NR2E1 (0.77) | MAP3K7MAP4K2ABL1SRCNR2E1 | |
| SCHEMBL12518522 | 0.79 | MAP4K2 (1.00) | MAPK14MAP3K20MAP3K7MAP4K2ABL1 | |
| SCHEMBL16581650 | 0.79 | CSK (0.60) | MAPK14MAP3K20MAP3K7MAP4K2ABL1 | |
| SCHEMBL16581606 | 0.79 | CSK (0.60) | MAPK14MAP3K20MAP3K7MAP4K2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519517-B1 | TYPE II RAF KINASE INHIBITORS | DANA FARBER CANCER INST INC (US) | 2015-03-25 | — | — | EP | claimed |