Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.62 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.62 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.62 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 10/20 | 0.61 |
| ▸ | BCR | P11274 | 8/20 | 0.61 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.60 |
| ▸ | RAF1 | P04049 | 2/20 | 0.59 |
| ▸ | BRAF | P15056 | 2/20 | 0.59 |
| ▸ | LDLR | P01130 | 3/20 | 0.59 |
| ▸ | KIT | P10721 | 3/20 | 0.59 |
| ▸ | PCSK9 | Q8NBP7 | 3/20 | 0.59 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.58 |
| ▸ | HCK | P08631 | 2/20 | 0.57 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.57 |
| ▸ | BTK | Q06187 | 1/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.57 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789491 | 0.87 | ABL1 (0.69) | MAPK14MAP3K20MAP3K7MAP4K2ABL1 | |
| SCHEMBL30447296 | 0.85 | MAPK14 (0.69) | MAPK14MAP3K20MAP3K7MAP4K2ABL1 | |
| SCHEMBL14953321 | 0.85 | ABL1 (0.78) | MAPK14MAP3K20MAP3K7MAP4K2ABL1 | |
| SCHEMBL24070682 | 0.85 | MAPK14 (0.69) | MAPK14MAP3K20MAP3K7MAP4K2ABL1 | |
| SCHEMBL29514885 | 0.85 | ABL1 (0.78) | MAPK14MAP3K20MAP3K7MAP4K2ABL1 | |
| SCHEMBL30339882 | 0.84 | MAPK14 (0.66) | MAPK14MAP3K20MAP3K7MAP4K2ABL1 | |
| SCHEMBL24070473 | 0.84 | MAPK14 (0.66) | MAPK14MAP3K20MAP3K7MAP4K2ABL1 | |
| SCHEMBL14642889 | 0.84 | ABL1 (0.78) | MAPK14MAP3K20MAP3K7MAP4K2ABL1 | |
| SCHEMBL13659898 | 0.84 | NR2E1 (0.77) | MAP3K7MAP4K2ABL1BCRNR2E1 | |
| SCHEMBL31620882 | 0.83 | LCK (0.70) | MAPK14MAP3K20ABL1BCRNR2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012000304-A1 | HETEROCYCLIC ALKYNYL BENZENE COMPOUNDS AND MEDICAL COMPOSITIONS AND USES THEREOF | 中国科学院广州生物医药与健康研究院 (CN) | 2012-01-05 | — | — | WO | disclosed |