Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 3/20 | 0.49 |
| ▸ | ABL1 | P00519 | 4/20 | 0.47 |
| ▸ | CSK | P41240 | 3/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.47 |
| ▸ | RAF1 | P04049 | 2/20 | 0.47 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.47 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.47 |
| ▸ | ABL2 | P42684 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.47 |
| ▸ | PIKFYVE | Q9Y2I7 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | BRAF | P15056 | 4/20 | 0.42 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.41 |
| ▸ | ARAF | P10398 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16581619 | 1.00 | SRC (0.49) | SRCABL1CSKMAPK14MAP3K20 | |
| SCHEMBL16581606 | 0.88 | CSK (0.60) | SRCABL1CSKMAPK14MAP3K20 | |
| SCHEMBL16581650 | 0.88 | CSK (0.60) | SRCABL1CSKMAPK14MAP3K20 | |
| SCHEMBL16581618 | 0.85 | CSK (0.63) | SRCABL1CSKMAPK14MAP3K20 | |
| SCHEMBL16581617 | 0.85 | CSK (0.63) | SRCABL1CSKMAPK14MAP3K20 | |
| SCHEMBL16581574 | 0.78 | MAPK14 (0.65) | SRCABL1MAPK14MAP3K20MAP3K7 | |
| SCHEMBL16581572 | 0.78 | MAPK14 (0.65) | SRCABL1MAPK14MAP3K20MAP3K7 | |
| SCHEMBL2284669 | 0.73 | MAPK14 (0.83) | SRCABL1CSKMAPK14MAP3K20 | |
| SCHEMBL29496497 | 0.73 | MAPK14 (0.83) | SRCABL1CSKMAPK14MAP3K20 | |
| SCHEMBL2284678 | 0.73 | MAPK14 (0.83) | SRCABL1CSKMAPK14MAP3K20 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519517-B1 | TYPE II RAF KINASE INHIBITORS | DANA FARBER CANCER INST INC (US) | 2015-03-25 | — | — | EP | claimed |
| US-9180127-B2 | Type II Raf kinase inhibitors | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-11-10 | — | — | US | disclosed |