Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.62 |
| ▸ | CES1 | P23141 | 2/20 | 0.62 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.59 |
| ▸ | BAD | Q92934 | 1/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3131476 | 0.93 | CES2 (0.71) | CES2CES1BCL2L1BADPTPN1 | |
| SCHEMBL1927476 | 0.82 | BCL2L1 (0.64) | CES2CES1BCL2L1BADPTPN1 | |
| SCHEMBL16595319 | 0.80 | BCL2L1 (0.68) | CES2CES1BCL2L1BADPTPN1 | |
| Hydrochloric Acid SCHEMBL30685286 | 0.80 | BCL2L1 (0.61) | CES2CES1BCL2L1BADPTPN1 | |
| SCHEMBL716295 | 0.78 | CES2 (1.00) | CES2CES1BCL2L1BADPTPN1 | |
| SCHEMBL9777084 | 0.77 | BCL2L1 (0.70) | CES2CES1BCL2L1BADPTPN1 | |
| SCHEMBL1864175 | 0.77 | BCL2L1 (0.70) | CES2CES1BCL2L1BADPTPN1 | |
| SCHEMBL9814506 | 0.77 | BCL2L1 (0.70) | CES2CES1BCL2L1BADPTPN1 | |
| SCHEMBL10313780 | 0.76 | CES2 (0.65) | CES2CES1BCL2L1BADPTPN1 | |
| SCHEMBL10704266 | 0.75 | BCL2L1 (0.67) | CES2CES1BCL2L1BADPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3046920-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES | BioMarin Pharmaceutical Inc. (US) | 2016-07-27 | — | — | EP | claimed |
| WO-2015042397-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES | BIOMARIN PHARMACEUTICAL INC. (US) | 2015-03-26 | — | — | WO | claimed |
| WO-2015042397-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES | BIOMARIN PHARMACEUTICAL INC. (US) | 2015-03-26 | — | — | WO | disclosed |