Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GHSR | Q92847 | 1/20 | 0.41 |
| ▸ | F13A1 | P00488 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | TGM1 | P22735 | 1/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.41 |
| ▸ | PREP | P48147 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1553438 | 1.00 | POLB (0.46) | POLBCYP2D6CYP2C9GRIN2BALDH1A1 | |
| Oxalic Acid SCHEMBL7332882 | 0.98 | CYP2D6 (0.44) | POLBCYP2D6CYP2C9GRIN2BALDH1A1 | |
| SCHEMBL6475964 | 0.82 | ALDH1A1 (0.47) | CYP2D6CYP2C9ALDH1A1GAACYP3A4 | |
| SCHEMBL6475969 | 0.82 | ALDH1A1 (0.47) | CYP2D6CYP2C9ALDH1A1GAACYP3A4 | |
| SCHEMBL5469953 | 0.80 | ALDH1A1 (0.51) | POLBCYP2D6CYP2C9GRIN2BALDH1A1 | |
| SCHEMBL5469955 | 0.80 | ALDH1A1 (0.51) | POLBCYP2D6CYP2C9GRIN2BALDH1A1 | |
| SCHEMBL1554396 | 0.80 | POLB (0.60) | POLBCYP2D6CYP2C9GRIN2BALDH1A1 | |
| SCHEMBL1554397 | 0.80 | POLB (0.60) | POLBCYP2D6CYP2C9GRIN2BALDH1A1 | |
| SCHEMBL8393648 | 0.80 | LMNA (0.58) | CYP2D6CYP2C9ALDH1A1GAACYP3A4 | |
| SCHEMBL6483802 | 0.79 | ALDH1A1 (0.53) | CYP2D6CYP2C9ALDH1A1GAACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3039126-A2 | SMALL MOLECULE CELLULAR REPROGRAMMING TO GENERATE NEURONAL CELLS | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone (US) | 2016-07-06 | — | — | EP | disclosed |
| WO-2015041809-A2 | SMALL MOLECULE CELLULAR REPROGRAMMING TO GENERATE NEURONAL CELLS | THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE (US) | 2015-03-26 | — | — | WO | disclosed |